Protein Info for RR42_RS05750 in Cupriavidus basilensis FW507-4G11
Annotation: fructose 2,6-bisphosphatase
These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.
Protein Families and Features
Best Hits
KEGG orthology group: K01834, phosphoglycerate mutase [EC: 5.4.2.1] (inferred from 81% identity to reh:H16_A1100)Predicted SEED Role
"Fructose-2,6-bisphosphatase"
KEGG Metabolic Maps
- Biosynthesis of alkaloids derived from histidine and purine
- Biosynthesis of alkaloids derived from ornithine, lysine and nicotinic acid
- Biosynthesis of alkaloids derived from shikimate pathway
- Biosynthesis of alkaloids derived from terpenoid and polyketide
- Biosynthesis of phenylpropanoids
- Biosynthesis of plant hormones
- Biosynthesis of terpenoids and steroids
- Glycolysis / Gluconeogenesis
Isozymes
Compare fitness of predicted isozymes for: 5.4.2.1
Use Curated BLAST to search for 5.4.2.1
Sequence Analysis Tools
PaperBLAST (search for papers about homologs of this protein)
Search CDD (the Conserved Domains Database, which includes COG and superfam)
Predict protein localization: PSORTb (Gram-negative bacteria)
Predict transmembrane helices and signal peptides: Phobius
Check the current SEED with FIGfam search
Find homologs in fast.genomics or the ENIGMA genome browser
See A0A0C4Y6E9 at UniProt or InterPro
Protein Sequence (244 amino acids)
>RR42_RS05750 fructose 2,6-bisphosphatase (Cupriavidus basilensis FW507-4G11) MELPPSPRRRIYLMRHGAVTYFDETGRPALPELVPLNETGRVQASAAGRAFAAENIGFDR IIVSGLPRTVETAERVVAALPGMADAAMETWPELQEIRGGKLQGISDDKLRDAFIGAFEG EVPEDKRFLDGESVGEFLDRVLPALRRLRDDPNWDTALLVLHGGTNRAILSHAITCGRRV FYGSLMQTAGCINVLDVGDDPLDWVVRMMNYSPPTPVHSGTRHTTMEVLLHQYLRFRDLR GPAS