Protein Info for RR42_RS05110 in Cupriavidus basilensis FW507-4G11

Annotation: betaine-aldehyde dehydrogenase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• TIGR03216: 2-hydroxymuconic semialdehyde dehydrogenase
  • amino acids 9 to 489 (481 residues), 851.7 bits, E=7.3e-261
• PF00171: Aldedh
  • amino acids 19 to 484 (466 residues), 533.1 bits, E=2.5e-164

Best Hits

Swiss-Prot: 62% identical to AMNC_PSESP: 2-aminomuconic 6-semialdehyde dehydrogenase (amnC) from Pseudomonas sp.

KEGG orthology group: K10217, aminomuconate-semialdehyde dehydrogenase [EC: 1.2.1.32] (inferred from 80% identity to pol:Bpro_5132)

MetaCyc: 75% identical to 2-aminomuconate 6-semialdehyde dehydrogenase (Pseudomonas fluorescens KU-7)
Aminomuconate-semialdehyde dehydrogenase. [EC: 1.2.1.32]

Predicted SEED Role

"2-aminomuconate semialdehyde dehydrogenase (EC 1.2.1.32)" (EC 1.2.1.32)

MetaCyc Pathways

• L-tryptophan degradation IX (11/12 steps found)
• L-tryptophan degradation XII (Geobacillus) (11/12 steps found)
• 2-amino-3-carboxymuconate semialdehyde degradation to 2-hydroxypentadienoate (4/4 steps found)
• 2-nitrobenzoate degradation I (6/7 steps found)
• 2-aminophenol degradation (3/4 steps found)
• 2-amino-3-carboxymuconate semialdehyde degradation to glutaryl-CoA (3/5 steps found)
• L-tryptophan degradation III (eukaryotic) (10/15 steps found)
• 4-chloronitrobenzene degradation (4/9 steps found)
• 4-nitrotoluene degradation II (4/9 steps found)
• L-tryptophan degradation XI (mammalian, via kynurenine) (11/23 steps found)

KEGG Metabolic Maps

• Benzoate degradation via hydroxylation
• Toluene and xylene degradation
• Tryptophan metabolism

Isozymes

Compare fitness of predicted isozymes for: 1.2.1.32

Use Curated BLAST to search for 1.2.1.32

Sequence Analysis Tools

See A0A0C4Y6A2 at UniProt or InterPro

Protein Sequence (489 amino acids)

>RR42_RS05110 betaine-aldehyde dehydrogenase (Cupriavidus basilensis FW507-4G11)
MPKQNIPLIRHYIDGEFVASAGTFPDTCPVDGHLVANVCEADAALVDRAVQAARRALQGP
WGQLDVQQRAALLHRIADGIEARFDAFVAAEVEDTGRPEHQARTLDVARAVTNLRTFADL
AKTAGNELYETPTADGAGALNYTVRKPVGVVGIISPWNLPLLLLTWKVAPALACGNTVVA
KPSEETPASAALLAEVIHQAGVPHGVFNLLHGFGGGSTGEFLTRHDGIDAITFTGESRTG
STIMRAVADGVKEISFELGGKNAAVVFADADFDAAVAGVLRSSFTNAGQVCLCSERVFVA
RPIFDAFVAALKARTQALKLGHPGDDGVDMGPLISRGHRDKVESYFRLAVEEGATVVCGG
KVPVFGDARDDGAYVMPTIWTGLPDSARCVTEEIFGPVCHIAPFDSEEEVIARVNDSAYG
LACALWTTNLTRAHRVARQVRVGLTWVNTWYLRDLRTPFGGVGLSGLGREGGRHSLDFYS
EVANICIKL