Protein Info for RR42_RS05085 in Cupriavidus basilensis FW507-4G11

Annotation: 2-aminomuconate deaminase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• PF01042: Ribonuc_L-PSP
  • amino acids 13 to 135 (123 residues), 95.2 bits, E=1.5e-31

Best Hits

Swiss-Prot: 68% identical to AMND_PSESP: 2-aminomuconate deaminase (amnD) from Pseudomonas sp.

KEGG orthology group: K15067, 2-aminomuconate deaminase [EC: 3.5.99.5] (inferred from 80% identity to put:PT7_3612)

MetaCyc: 75% identical to 2-aminomuconate deaminase (Pseudomonas fluorescens KU-7)
2-aminomuconate deaminase. [EC: 3.5.99.5]

Predicted SEED Role

No annotation

MetaCyc Pathways

• L-tryptophan degradation IX (11/12 steps found)
• L-tryptophan degradation XII (Geobacillus) (11/12 steps found)
• 2-amino-3-carboxymuconate semialdehyde degradation to 2-hydroxypentadienoate (4/4 steps found)
• 2-nitrobenzoate degradation I (6/7 steps found)
• 2-aminophenol degradation (3/4 steps found)
• 2-amino-3-carboxymuconate semialdehyde degradation to glutaryl-CoA (3/5 steps found)
• L-tryptophan degradation III (eukaryotic) (10/15 steps found)
• 4-nitrotoluene degradation II (4/9 steps found)
• L-tryptophan degradation XI (mammalian, via kynurenine) (11/23 steps found)

KEGG Metabolic Maps

• Tryptophan metabolism

Isozymes

No predicted isozymes

Use Curated BLAST to search for 3.5.99.5

Sequence Analysis Tools

See A0A0C4Y698 at UniProt or InterPro

Protein Sequence (140 amino acids)

>RR42_RS05085 2-aminomuconate deaminase (Cupriavidus basilensis FW507-4G11)
MTTLSKVLTGKATPRGRFPHVKRAGDFLFVSGTSSRRADNSFAGASADAMGVTALDIHEQ
TRAVIGNIREILQSVGCDLSDLVEITTFLVNMNDFGGYNEVYGEYFDYDGPTRTTVAVHQ
LPHPHLLIEIKAVAYQPLPR