Protein Info for RR42_RS04230 in Cupriavidus basilensis FW507-4G11

Annotation: dihydrodipicolinate synthase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

Best Hits

Swiss-Prot: 35% identical to DAPA_HALMA: 4-hydroxy-tetrahydrodipicolinate synthase (dapA) from Haloarcula marismortui (strain ATCC 43049 / DSM 3752 / JCM 8966 / VKM B-1809)

KEGG orthology group: K01714, dihydrodipicolinate synthase [EC: 4.2.1.52] (inferred from 65% identity to rme:Rmet_0666)

Predicted SEED Role

"4-hydroxy-tetrahydrodipicolinate synthase (EC 4.3.3.7)" (EC 4.3.3.7)

MetaCyc Pathways

aspartate superpathway (23/25 steps found)
superpathway of L-lysine, L-threonine and L-methionine biosynthesis I (16/18 steps found)
L-lysine biosynthesis I (9/9 steps found)
superpathway of L-lysine, L-threonine and L-methionine biosynthesis II (13/15 steps found)
L-lysine biosynthesis III (6/7 steps found)
L-lysine biosynthesis VI (6/7 steps found)
L-lysine biosynthesis II (7/9 steps found)
dipicolinate biosynthesis (3/4 steps found)

KEGG Metabolic Maps

Isozymes

Compare fitness of predicted isozymes for: 4.2.1.52, 4.3.3.7

Use Curated BLAST to search for 4.2.1.52 or 4.3.3.7

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A0A0C4Y091 at UniProt or InterPro

Protein Sequence (302 amino acids)

>RR42_RS04230 dihydrodipicolinate synthase (Cupriavidus basilensis FW507-4G11)
MQAVDQVQQAFSGIWLPLVTPFADGSVDFPALARLVAHYAGSGIAGIVVCGSTGEAAALD
EAEQLAVLDTVLASAGSLPVMMGVAGSQVKQVQARVRRLAGLPLAGLLAPAPYYVRPSQA
GLLDYFRTLADSAAAPLVLYDIPYRTGVKLETETILALAAHPNIRAIKDCGGDYHGTQAV
IADARLSVLAGEDHQLLGTLCLGGAGAIIASAHLYPALFVALAQAVAGQRLEHARRLFHA
VMPVIKLLFAEPNPGPLKAMLAREGWTRNELRAPMKSAGAALEAALAQACERLGAVVPEL
LG