Protein Info for RR42_RS04005 in Cupriavidus basilensis FW507-4G11

Annotation: carbon monoxide dehydrogenase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 600 650 700 747 PF20256: MoCoBD_2" amino acids 62 to 234 (173 residues), 48.2 bits, see alignment E=1.1e-16 amino acids 616 to 699 (84 residues), 36.5 bits, see alignment E=4.1e-13 PF02738: MoCoBD_1" amino acids 339 to 574 (236 residues), 73.2 bits, see alignment E=1.9e-24

Best Hits

KEGG orthology group: K07303, isoquinoline 1-oxidoreductase, beta subunit [EC: 1.3.99.16] (inferred from 81% identity to reh:H16_A0701)

Predicted SEED Role

"Isoquinoline 1-oxidoreductase beta subunit (EC 1.3.99.16)" in subsystem N-heterocyclic aromatic compound degradation (EC 1.3.99.16)

Isozymes

Compare fitness of predicted isozymes for: 1.3.99.16

Use Curated BLAST to search for 1.3.99.16

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A0A0C4Y066 at UniProt or InterPro

Protein Sequence (747 amino acids)

>RR42_RS04005 carbon monoxide dehydrogenase (Cupriavidus basilensis FW507-4G11)
MRIRYLEALAGGNRGHAHAGGAAALDRRSFLKLTGFAGGGLALGILPAQAALAQEGAAPK
APPSPPQAFLLIAPDNTVTVAVNRLEFGQGVHTALPMALAEELDVDWRNVRATLAPAGDA
YKDPAFGMQMTGGSTALNHSFQQYRELGARARAMLVAAAATQWQVDPSSCQVALGVVTAG
SHRATFGELAQAAMALPVPQQVTLKNPAQFKLIGKPTRRLDARGKLEATTAFGIDVHLKN
MVVAVVARPPRFGGKVKSFNADKARAIKGVADVMLVPVDRGGTGVAVVANGYWPAKQARD
ALEIVWEDSGSSVSTKDLFAQYRTLAAQPGTVALQADMGAMSGAARTISADYEFPYLAHA
PMEPLNCTLQAEVSGKAVQSVKVWVGSQFQTVDQAAIGRVLGLAPAKVTLNTMMAGGGFG
RRAVPTSDYLVEAANVLLAWVKNGHDEPLKVMWSREDDIRGGYYRPLHVHRARIGTDAKG
QVLGWQHTVVGQSILSGTPFEAFMVKGGVDSTMVEGLVENDYGFPLQLSVHHPQVAVPVL
WWRSVGNTHTAFVKETLVDEVAVNARQDPVAYRLARLDAGKHARHRAALQLAVDKSGYGK
RKLPKGQAWGVAVHESFGTVVAYVVEVSLVKNEPHVHRVTAGVHANRVVNPMSAEAQVQG
ACVFGLAMTRPGFAIEIENGAVKNSNFPDYPPPRITDAPVVDVFFVPSEDPPTGLGEPGV
PAIAPAVANALFTLTGKRQRQLPFVLA