Protein Info for RR42_RS03980 in Cupriavidus basilensis FW507-4G11

Annotation: Fis family transcriptional regulator

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 440 PF00072: Response_reg" amino acids 8 to 116 (109 residues), 106 bits, see alignment E=4.4e-34 PF00158: Sigma54_activat" amino acids 147 to 313 (167 residues), 231.5 bits, see alignment E=1.7e-72 PF14532: Sigma54_activ_2" amino acids 148 to 318 (171 residues), 82.4 bits, see alignment E=1.3e-26 PF07728: AAA_5" amino acids 170 to 286 (117 residues), 34.6 bits, see alignment E=6.3e-12 PF02954: HTH_8" amino acids 398 to 438 (41 residues), 39.7 bits, see alignment 1.1e-13

Best Hits

Swiss-Prot: 57% identical to DCTD_PSEAE: C4-dicarboxylate transport transcriptional regulatory protein DctD (dctD) from Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)

KEGG orthology group: K10126, two-component system, NtrC family, C4-dicarboxylate transport response regulator DctD (inferred from 86% identity to cti:RALTA_A0649)

Predicted SEED Role

"Nitrogen regulation protein NR(I)" in subsystem Ammonia assimilation

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A0A0C4YC77 at UniProt or InterPro

Protein Sequence (440 amino acids)

>RR42_RS03980 Fis family transcriptional regulator (Cupriavidus basilensis FW507-4G11)
MEPAPLTVLIVEDDPDVRLGCEQALRLEGIATRAVASAEAALREVGNHFPGVVVSDIRLP
GIDGMALLHELRSRDDALPVVMVTGHGDVSLAVQAMKAGAYHFLEKPFSPERLVEVAQRA
LEKRRLVLEVAELRRKLAGRDTLQARLIGHSPSIERLRKLIADLADTAANVLIHGETGTG
KELVARCLHEASSRRARHFVPINCGGLPEQLFESEIFGHEAGSFTGAARRRIGKIEHAEG
GTLFLDEIESMPMQMQIKLLRVLQERVVERLGSNTPVPVNTRVVAATKADLKALSAAGQF
RADLYYRLNVVTLELPPLRERREDVPPLFEHFVAQAALRFEREAQPATPAELAALMAYPW
PGNVRELRNLAERHVLGLGCNPGQGTAEPAALPLAQAVEQFERAMIADAMRRHEGNLSRA
SEALGIAKTTLFDKVRKYRL