Protein Info for RR42_RS03030 in Cupriavidus basilensis FW507-4G11

Updated annotation (from data): required for 4-hydroxybenzoate transport, together with NodT, MFP, and FUSC proteins (RR42_RS03040, RR42_RS03035, and RR42_RS03025)
Rationale: PFam PF07869.8 (DUF1656). Specifically important for utilization of 4-hydroxybenzoate (at 20 mM). Not clear if this system is for uptake or for efflux (as this compound is likely to be toxic at 20 mM)
Original annotation: membrane protein

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 25 50 69 transmembrane" amino acids 15 to 38 (24 residues), see Phobius details amino acids 47 to 65 (19 residues), see Phobius details PF07869: DUF1656" amino acids 4 to 59 (56 residues), 83.4 bits, see alignment E=4.6e-28

Best Hits

KEGG orthology group: None (inferred from 71% identity to rme:Rmet_4792)

Predicted SEED Role

"membrane protein, putative"

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A0A0C4XZP8 at UniProt or InterPro

Protein Sequence (69 amino acids)

>RR42_RS03030 required for 4-hydroxybenzoate transport, together with NodT, MFP, and FUSC proteins (RR42_RS03040, RR42_RS03035, and RR42_RS03025) (Cupriavidus basilensis FW507-4G11)
MSGEVDVYGVFVPSLLAWMLVAFLITACARAVLAHVGFYRLVWHRSLFNLALYVIVLGGI
VYLAYRLQS