Protein Info for RR42_RS02365 in Cupriavidus basilensis FW507-4G11

Annotation: carbon monoxide dehydrogenase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 600 650 700 750 793 PF01315: Ald_Xan_dh_C" amino acids 24 to 144 (121 residues), 107.4 bits, see alignment E=7.8e-35 PF02738: MoCoBD_1" amino acids 159 to 408 (250 residues), 261 bits, see alignment E=1.3e-81 PF20256: MoCoBD_2" amino acids 434 to 723 (290 residues), 315.1 bits, see alignment E=7.4e-98

Best Hits

KEGG orthology group: None (inferred from 91% identity to reu:Reut_A0424)

Predicted SEED Role

"Carbon-monoxide dehydrogenase form II, large subunit (EC 1.2.99.2)" in subsystem CO Dehydrogenase (EC 1.2.99.2)

KEGG Metabolic Maps

Isozymes

Compare fitness of predicted isozymes for: 1.2.99.2

Use Curated BLAST to search for 1.2.99.2

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A0A0C4Y6W9 at UniProt or InterPro

Protein Sequence (793 amino acids)

>RR42_RS02365 carbon monoxide dehydrogenase (Cupriavidus basilensis FW507-4G11)
MNAPDNQHLIGASVKRKEDYRFLTGNGQYTDDIVLPQQSYGYFLRSPHAHARIVSIDKTE
ALASPGVVAIFTGDDVAADKVGGLPCGWLIHSIDGSPMKEPAHPVLAQGKARHVGDQVAL
VIAETLQQAKDAAEKIDVQYDELPAVVNTAHAASATSLVHDDVPENTSYVWGHGDRAATD
AAFAKAAHVTTLEIINNRLIPNAIEPRAVNASYTRQDDSYTVYVSNQNPHVERLLMGAFV
LGLPESRLRIIAPDVGGGFGSKIFLYAEDVALTWASKKIKRPIKWTAERSESFLTDAHGR
DHVTKAELAMDADGKFLAMRVHTTANMGAYLSTFASSVPTILYATLLAGQYATPAIYAEV
RAVFTNTAPVDAYRGAGRPEATYVVERLVEAAAREMKMDPAQIRRKNFIHDFPYATPVGL
TYDTGDYEPCLARAQELADVKGFPARREEAKQRGKLRGLGYSCYIEACGLAPSNIAGALG
ARAGLFEVGEIRVHPTGTVTVFTGSHSHGQGHETTFAQIVADRLGIALDAVEVVHGDTGR
VPFGMGTYGSRSLSVGGSAIMKALDKIEAKAKKIAAHLLEASDADIEFKNGTFSVAGTDR
SKTFGEVALTAYVPHNYPLDKLEPGLNENAFYDPTNFTYPSGAYICEVEVDPDTGESKVI
KFTAVDDFGNIINPMIVEGQVHGGIGQGLGQAMLEQCVYDDDSGQLLTGSYMDYAMPRAG
DLPDFTVETAKGTPCTHNPLGVKGCGEAGAIGSPPAFINALVDALSPLGVHDIQMPATPH
RVWQDIRLAQAPN