Protein Info for RR42_RS02360 in Cupriavidus basilensis FW507-4G11

Annotation: carbon monoxide dehydrogenase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• PF00941: FAD_binding_5
  • amino acids 3 to 167 (165 residues), 159.8 bits, E=2.8e-51

Best Hits

KEGG orthology group: K03519, carbon-monoxide dehydrogenase medium subunit [EC: 1.2.99.2] (inferred from 87% identity to reu:Reut_A0423)

MetaCyc: 36% identical to NdhA (Paenarthrobacter nicotinovorans)
Nicotine dehydrogenase. [EC: 1.5.99.4]; 1.5.99.4 [EC: 1.5.99.4]

Predicted SEED Role

"Carbon monoxide dehydrogenase medium chain (EC 1.2.99.2)" in subsystem CO Dehydrogenase (EC 1.2.99.2)

MetaCyc Pathways

• nicotine degradation III (VPP pathway) (6/10 steps found)
• nicotine degradation I (pyridine pathway) (6/17 steps found)

KEGG Metabolic Maps

• Methane metabolism
• Nicotinate and nicotinamide metabolism
• Trinitrotoluene degradation

Isozymes

Compare fitness of predicted isozymes for: 1.2.99.2

Use Curated BLAST to search for 1.2.99.2 or 1.5.99.4

Sequence Analysis Tools

See A0A0C4Y4V7 at UniProt or InterPro

Protein Sequence (266 amino acids)

>RR42_RS02360 carbon monoxide dehydrogenase (Cupriavidus basilensis FW507-4G11)
MYAFNFERAADTKAAVDKLKADPDAKYLGGGQSLLAAMKLRLAAPSALIDVARIPGMADI
RVENDELVIGAAARHADVAANADVRKRIPALAALADGIGDRQVRAMGTLGGSLANDDPAA
CYPAAVLALNATVVTDRRNIAADSFFRSLYETALEPDELITAVRFPTPDKAAYIKFRNPA
SRFALVGVMVAQFGKVVRVAVTGAADCVFRSAPLEQALAASFTPAAARAVVVDASKLNTD
LHASAEYRAHLIPVLAARAVEQALKG