Protein Info for RR42_RS02350 in Cupriavidus basilensis FW507-4G11

Annotation: VWA domain-containing protein

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 431 PF05762: VWA_CoxE" amino acids 170 to 390 (221 residues), 248.1 bits, see alignment E=6.7e-78 PF13519: VWA_2" amino acids 229 to 329 (101 residues), 33 bits, see alignment E=8e-12

Best Hits

KEGG orthology group: K07161, (no description) (inferred from 82% identity to reh:H16_A0435)

Predicted SEED Role

"carbon monoxide dehydrogenase E protein" in subsystem CO Dehydrogenase or Carbon monoxide dehydrogenase maturation factors

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A0A0C4YBC7 at UniProt or InterPro

Protein Sequence (431 amino acids)

>RR42_RS02350 VWA domain-containing protein (Cupriavidus basilensis FW507-4G11)
MPRLHPDAPLAAVPPAGTLPMLARNVTHFVRLLRDAGFALSPAQAVDTLLALQYVDIGRR
DEVRAAMAALMVSGPDQRLLFDAAFDLFWRDPDWEGKLRALLLPRVDAGAPPPPRNNRLA
DALAAQRPPESGRRGEDHVERFTAPLTFSAQERLAQRDFETLGAEEWRALQHMIRARHAR
LATERTRRLRAAASGPHADLRASARLAVRQQGEWLRWKYRRRAERRPPLVLLLDISGSMS
QYSRAVLYFCHALMQSRERLHVFLFGTRLTNITRWLRERDPDEAVGAITGQVRDWAGGTR
IGAALATFNRQWARRTLSGRATVLLVTDGLDHEDIDLLDAEMARLRRFAHRIVWLNPLLR
YAGFMPQARGVQAILPHVDALRSAHNLDSLFALESLLAARETLAMPVFTAVPGPGDIKNM
KDTKETPRPWK