Protein Info for RR42_RS01710 in Cupriavidus basilensis FW507-4G11

Annotation: tyrosine ammonia-lyase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• TIGR03832: tyrosine 2,3-aminomutase
  • amino acids 8 to 514 (507 residues), 892.7 bits, E=3.1e-273
• PF00221: Lyase_aromatic
  • amino acids 13 to 493 (481 residues), 571.9 bits, E=4.8e-176

Best Hits

Swiss-Prot: 85% identical to TALY_CUPMC: Tyrosine ammonia-lyase (Rmet_0231) from Cupriavidus metallidurans (strain ATCC 43123 / DSM 2839 / NBRC 102507 / CH34)

KEGG orthology group: K01745, histidine ammonia-lyase [EC: 4.3.1.3] (inferred from 85% identity to rme:Rmet_0231)

Predicted SEED Role

"Histidine ammonia-lyase (EC 4.3.1.3)" in subsystem Histidine Degradation (EC 4.3.1.3)

MetaCyc Pathways

• L-histidine degradation II (5/5 steps found)
• L-histidine degradation VI (7/8 steps found)
• L-histidine degradation I (4/4 steps found)
• L-histidine degradation III (4/6 steps found)

KEGG Metabolic Maps

• Histidine metabolism
• Nitrogen metabolism

Isozymes

Compare fitness of predicted isozymes for: 4.3.1.3

Use Curated BLAST to search for 4.3.1.3

Sequence Analysis Tools

See A0A0C4YB27 at UniProt or InterPro

Protein Sequence (532 amino acids)

>RR42_RS01710 tyrosine ammonia-lyase (Cupriavidus basilensis FW507-4G11)
MGGTAVEVDGQQLTAAALAQVAQGRRPASLDQAARAHVADARARFEELASSNIPIYGVST
GFGELVHNWVDIEHAGALQENLLRSHCAGVGPLFGREEVRAMMVARANALARGYSAVRPL
VIEQLLRYVEAGITPAVPQVGSLGASGDLAPLSHIAITLIGEGKVLLADGTTAPTGQVLR
EHGIEPIKLSHKEGLALINGTSAMTGMACLLLETMRAQVTQAEIIAALALEGLNASADAF
MTHGHDIAKPHPGQVQSAANLRALLAGSTRLSGHGQLAGEMKTRAGDEKNTGTGVFIQKA
YTLRCIPQVLGAVRDTLGHCATVVERELNSSNDNPLFFDDGELFHGGNFHGQQVAFAMDF
LAIAATQLGVVSERRLNRLLSPHLNNGLPAFLAAANEGLSCGFAGAQYPATALIAENRTI
CSPASIQSVPSNGDNQDVVSMGLIGARNARRIIDNNQYILAVELLAACQAAELAGAVESL
SPAGRAVFAFVRERVPFLAMDRYMTDDIEAIAAQLRAGALVGVVRAAGAAVN