Protein Info for RR42_RS01150 in Cupriavidus basilensis FW507-4G11

Annotation: histidine kinase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 480 transmembrane" amino acids 6 to 27 (22 residues), see Phobius details amino acids 184 to 208 (25 residues), see Phobius details PF00672: HAMP" amino acids 205 to 252 (48 residues), 29.6 bits, see alignment 1.1e-10 PF00512: HisKA" amino acids 260 to 319 (60 residues), 50.2 bits, see alignment E=3.2e-17 PF02518: HATPase_c" amino acids 367 to 479 (113 residues), 80.4 bits, see alignment E=2e-26

Best Hits

KEGG orthology group: K07641, two-component system, OmpR family, sensor histidine kinase CreC [EC: 2.7.13.3] (inferred from 78% identity to reu:Reut_A0184)

Predicted SEED Role

"Two-component response regulator CreC"

Isozymes

Compare fitness of predicted isozymes for: 2.7.13.3

Use Curated BLAST to search for 2.7.13.3

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A0A0C4YAV6 at UniProt or InterPro

Protein Sequence (480 amino acids)

>RR42_RS01150 histidine kinase (Cupriavidus basilensis FW507-4G11)
MHIGLRIFLGFFLIVGLAAFLTLRVFVQEVKPGVRQAMEDTLVDTAHVLAVLAADDMKNG
RIANGAFARRLARLREDKVDANVWGMHKDAVGYRIYITDERGIVRFDSGEAAVGADYSRW
NDVYRTLRGEYGARSTRANPDDDASTVMHVAAPIRDGSKTIGVLTVAKPNVTMAPFIERS
QRKILLNGLLLMGGAFVIGLACTLWLVHGLRRLQRYARAVASGERAEMPLRGASELAELG
RSVESMRLRLEDKQYVEHYIHTLTHEMKSPLAAISGAAELLQEDMPAADRNRFVANIRRQ
AQRLEEMIRKLLALAALEQRQSLETHAPVALEPLIEQLLHELEPRARQRDLTLRLLPPGQ
PAAVVRGDPFLLHQALGNLLENAIDFAPAASMVDVCVAHGNAPANMIAVRVSDHGPGVPD
YALPRLFERFYSLPRPGGQDKSTGLGLCFVREIATLHRGDITLANRAEGGACATLTLPAA