Protein Info for RR42_RS00505 in Cupriavidus basilensis FW507-4G11

Annotation: histidine kinase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 600 650 678 signal peptide" amino acids 1 to 21 (21 residues), see Phobius details transmembrane" amino acids 180 to 202 (23 residues), see Phobius details amino acids 209 to 230 (22 residues), see Phobius details amino acids 245 to 267 (23 residues), see Phobius details amino acids 277 to 301 (25 residues), see Phobius details amino acids 307 to 326 (20 residues), see Phobius details amino acids 333 to 351 (19 residues), see Phobius details amino acids 366 to 385 (20 residues), see Phobius details PF07696: 7TMR-DISMED2" amino acids 33 to 168 (136 residues), 118 bits, see alignment E=6e-38 PF07695: 7TMR-DISM_7TM" amino acids 180 to 383 (204 residues), 87.6 bits, see alignment E=2.2e-28 PF00512: HisKA" amino acids 443 to 501 (59 residues), 42.8 bits, see alignment 9e-15 PF02518: HATPase_c" amino acids 554 to 661 (108 residues), 90.9 bits, see alignment E=1.5e-29

Best Hits

KEGG orthology group: None (inferred from 64% identity to bur:Bcep18194_B1562)

Predicted SEED Role

"Signal transduction histidine kinase"

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A0A0C4YAH9 at UniProt or InterPro

Protein Sequence (678 amino acids)

>RR42_RS00505 histidine kinase (Cupriavidus basilensis FW507-4G11)
MLRLFWIVLLCWLGHSAAWAEMRLPPAGEVSLGEHWELLRDPQDVLTIEQLSRPEFAAAF
QPQHSPPALGYVKGAVWLRITLTRPEQAAPVWLLELRSALLDDVTLFEPLAAGGYAQRVS
GDRRPVAGRDVDYRNPVFQLDLPVDKPVTLYLRVRSTSTMSFPLVAWSPEAFISFIGTEL
LLFGLFYAAHLVLLITSVWFYWVTRNLSFGLFSLTVLANLFTSLSAEGFTYQYLLPGWPL
TSDAVYVVSWFFATPLGTLFTAHYLGLYESPWRRWAIGFSLLAWGVALVMTPCLLLGNVW
WIRPLALLWGLITMGILLIASAVMTWRGQKAARVLLFVLVLLFGGTVLRLARNVGAIDPG
PFVDNANYLGMMAFLLIMNSAISWRYTDMRAEKEAAQAEALRVARQAERDLEVKVALRTQ
ALRSAMAQVEASLSLERRAQEEQRQFLSTVSHELRTPLAVIDATAQNLDLDDAHDDPQTS
ARYQKILRATQRLTMLLNDSLHEDGFELLRHGSRPSPTRLADLLEDAAAAAQLLSEGHRL
EVDGERLPETFPCDASLLRLALRTLADNAVKYTPAGCRVVLRGREVAEGVELEVQDNGPG
IEATDLPRVFERFYRGQNAGQKPGTGLGLSLARRMVEMQGGTLTLDSAPGQGCRATIFLP
SAPQGVQAQASAMGAANV