Protein Info for RR42_RS00495 in Cupriavidus basilensis FW507-4G11

Annotation: histidine kinase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 600 650 700 750 800 850 900 950 977 transmembrane" amino acids 372 to 390 (19 residues), see Phobius details amino acids 453 to 469 (17 residues), see Phobius details amino acids 473 to 492 (20 residues), see Phobius details amino acids 499 to 516 (18 residues), see Phobius details amino acids 527 to 549 (23 residues), see Phobius details PF02702: KdpD" amino acids 31 to 242 (212 residues), 306.5 bits, see alignment E=2e-95 PF13493: DUF4118" amino acids 453 to 559 (107 residues), 111.5 bits, see alignment E=4.4e-36 PF13492: GAF_3" amino acids 579 to 698 (120 residues), 56.7 bits, see alignment E=8.7e-19 PF00512: HisKA" amino acids 718 to 783 (66 residues), 61.2 bits, see alignment 1.9e-20 PF02518: HATPase_c" amino acids 829 to 938 (110 residues), 85.3 bits, see alignment E=1e-27

Best Hits

KEGG orthology group: K07646, two-component system, OmpR family, sensor histidine kinase KdpD [EC: 2.7.13.3] (inferred from 77% identity to reh:H16_B0895)

Predicted SEED Role

"Osmosensitive K+ channel histidine kinase KdpD (EC 2.7.3.-)" in subsystem Potassium homeostasis (EC 2.7.3.-)

Isozymes

Compare fitness of predicted isozymes for: 2.7.13.3, 2.7.3.-

Use Curated BLAST to search for 2.7.13.3 or 2.7.3.-

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A0A0C4Y5W5 at UniProt or InterPro

Protein Sequence (977 amino acids)

>RR42_RS00495 histidine kinase (Cupriavidus basilensis FW507-4G11)
MPDTAQRDAPGRPDPDALLQRMQQEGERAARGKLRVYFGASAGVGKTFAMLTAARALREQ
GSDVVIGVVETHGRAETEALIAGLERLPMKAMPHHKLDDRVLQEFDLDGALARRPALILV
DELAHSNASGSRHPKRWQDIEELLSAGIDVWTTVNVQHLDSLNEAVGGITGIRVWETVPD
TVFDDADEVILVDLPADELLRRLRDGKVYLPEQARTAATNFFRKGNLIALRELALRRTAD
RVDDDVRAYRHAESIRPVWRTREAVLACIGTGDDAAQVVKSARRLAGQLDCDWHVVTVAT
PRLAPLGGHERANIEEAMRLAEELGARTETLAGSDIVQAVAGYVRRHNLTKVVVGRAPGN
WRRSGGSLLARGRALLALGLSPFLGARAWLFGRHSFADSLALGCPEIDVIRVAADAMGAD
TRGRAQPAGGRADVREDPAPNDDSSVVAHRIDYLWAVAWCGGASLLSALTRPWFDLVNIA
MLFLAAVVGVALRHGRGPAALASVLSVAAFDFFFVPPRMSFAVSDVQYLVTFAVLLTVGL
VIGQLTAGLREQAQVSVERETDARTLYELARELSAALMPEQIIDISSRFLQAALGARSAF
FLVSPKGRLLPPVIDPTQRGNDAIDPVLAQWVFDHGQPAGTGTHTLPGSTVLYLPLKAPM
QTRGVLAVEPQKWRAFARPERRRQIDVFATLIAIAIERLHYVEVAQQALVSMESERLRSS
LLAAVSHDLRTPLTSLIGMAETMQRTEPPLPASLSETVDAMREQALRMRTMVVNLLDMAR
LQSRDVRMQKEWQSLEELVGAALAGMRDALSRHRVSVADLSALPLVECDAVLMERVLCNL
LENAAKYTPPGTGIRISGEVAETEVRLAVADDGPGVPRGQELSIFQKFTRGERESATAGV
GLGLAVCEAIVQAHGGRIWVESVNADHTGARFVVALPRGNPPAIEPEPPEALESALLAAH
GNGGVPVAHDAANKESS