Protein Info for RR42_RS00340 in Cupriavidus basilensis FW507-4G11

Annotation: glutathione S-transferase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• PF13409: GST_N_2
  • amino acids 10 to 79 (70 residues), 38.8 bits, E=2.8e-13
• PF13417: GST_N_3
  • amino acids 13 to 83 (71 residues), 31.1 bits, E=6.1e-11
• PF00043: GST_C
  • amino acids 106 to 194 (89 residues), 51.1 bits, E=3.4e-17
• PF14497: GST_C_3
  • amino acids 109 to 198 (90 residues), 35.2 bits, E=2.9e-12
• PF13410: GST_C_2
  • amino acids 138 to 188 (51 residues), 36 bits, E=1.5e-12

Best Hits

KEGG orthology group: K00799, glutathione S-transferase [EC: 2.5.1.18] (inferred from 76% identity to reh:H16_A0066)

Predicted SEED Role

"Glutathione S-transferase (EC 2.5.1.18)" in subsystem Glutathione: Non-redox reactions (EC 2.5.1.18)

MetaCyc Pathways

• 4-hydroxy-2-nonenal detoxification (1/4 steps found)
• pentachlorophenol degradation (5/10 steps found)
• glutathione-mediated detoxification I (3/8 steps found)
• gliotoxin biosynthesis (2/9 steps found)
• glutathione-mediated detoxification II (1/9 steps found)
• indole glucosinolate activation (intact plant cell) (3/12 steps found)
• camalexin biosynthesis (2/12 steps found)

KEGG Metabolic Maps

• Drug metabolism - cytochrome P450
• Glutathione metabolism
• Metabolism of xenobiotics by cytochrome P450

Isozymes

Compare fitness of predicted isozymes for: 2.5.1.18

Use Curated BLAST to search for 2.5.1.18

Sequence Analysis Tools

See A0A0C4XYG2 at UniProt or InterPro

Protein Sequence (208 amino acids)

>RR42_RS00340 glutathione S-transferase (Cupriavidus basilensis FW507-4G11)
MKLYYAPGACSLAVHIALREAGLPFSLAKVDLARHKLTEPESGSDDFYAVSPRGYVPLLQ
LDDGSRHTEAASLLQYVADLAPSKALLPAAGTRARLEAVGWLTLVSTELHKVFSPWLWHK
ETAQSTREDCKAKVALRFAELDRHLATRDYLCGTQFTVADAYCFAVANWANLLSMPLNPY
PALQAYLSRVAARPKVHEALVAEGLARD