Protein Info for RALBFv3_RS18780 in Ralstonia solanacearum IBSBF1503

Annotation: CusA/CzcA family heavy metal efflux RND transporter

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 100 200 300 400 500 600 700 800 900 1031 signal peptide" amino acids 1 to 39 (39 residues), see Phobius details transmembrane" amino acids 334 to 353 (20 residues), see Phobius details amino acids 359 to 377 (19 residues), see Phobius details amino acids 384 to 405 (22 residues), see Phobius details amino acids 433 to 454 (22 residues), see Phobius details amino acids 464 to 489 (26 residues), see Phobius details amino acids 522 to 541 (20 residues), see Phobius details amino acids 856 to 874 (19 residues), see Phobius details amino acids 882 to 902 (21 residues), see Phobius details amino acids 908 to 932 (25 residues), see Phobius details amino acids 953 to 972 (20 residues), see Phobius details amino acids 984 to 1009 (26 residues), see Phobius details TIGR00914: heavy metal efflux pump, CzcA family" amino acids 6 to 1013 (1008 residues), 933.2 bits, see alignment E=9.3e-285 PF00873: ACR_tran" amino acids 8 to 1009 (1002 residues), 861.2 bits, see alignment E=9.9e-263 PF03176: MMPL" amino acids 329 to 521 (193 residues), 28.2 bits, see alignment E=9.3e-11

Best Hits

KEGG orthology group: K07239, heavy-metal exporter, HME family (inferred from 96% identity to rsl:RPSI07_mp1077)

Predicted SEED Role

"Cobalt-zinc-cadmium resistance protein CzcA; Cation efflux system protein CusA"

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (1031 amino acids)

>RALBFv3_RS18780 CusA/CzcA family heavy metal efflux RND transporter (Ralstonia solanacearum IBSBF1503)
MMFNPIAAILKRRLLIVFLAVALLAVGVLSFRSLPLQAYPGVAPLSVQAITQWPGRSTTE
VEQQITIPIENALAGVPDVQSFRSVSLFGLSVVTLKFKEGTDSFKARQNFSQYLAGASLP
TGVQSSLSPDSDATGEIMRFRLVGDGVDLTTLKSYEDYDVTKELKHVQGVADVTSFGGQV
KEYHIVPSPAKLQSYGITLAQLIAAIGNANNNTGGNLLPAGEQQFVVRGVGLLQTADDIR
NVVVAANGGVPVHVRDIAEVEIGHVQRLGMVQYNDKPDVVEGIVLLKRDANATEVLAKVR
DSIREINGGILPRSVQIKPFYDRQALLDITMGTVEHTLVVGIALVLAVLFAFLGNLRAAA
VVAAVIPLALCVSFISMEHFHVPANLISLGAIDFGVIVDAAVIVMENIMRHLEEGAEKLD
DAIVKATSEVQRAMIFSTGIIIVAYSPLFFIGGVEGIIFKPMAFTMGFALLASIVLSLTF
VPATTSFVFGKTLHPHSPRFIVALLRWYKPLLRKLIRRPKTVFATALAALGLTLYSATFL
GTEFLPTLEENNLWLRITLPNTVDLDYSASVANDLRTYFAKQPEIKQVSVQIGRPDDGTD
STGVFNQEYGLYFAAPDQWGPGVTKADVVARLSKHLERIPGIEYNFSQYIQDNVDEALSG
VKGENSVKLFGSDLNVLEAKANEIQAQLRKIRGLVDVGIFRELGQPTLNVSIDRQAAARF
NINVSDVQNLVQYAIGGAPVTQILEGEKSFGLAVRLNPQARASYDAIRELLIDTPDGQRI
PLSMIAKVEMTDGPFFIYREMGKRYIAIKFGVRQRDLGGAVDEAQHAVASHVKLPEGYTI
KWDGQFNEMKVAQGKLIVIVPLTILVIFLLLYSTFGNFKDALMVVLNVPFAAIGGLLALH
LANETLSISAGIGFLSLFGIAIQDGVILISYVNRLAQSENLREATVEGAALRLRPVIMTA
MLAGLGLLPAALSHGIGSEAQRPLALVIVGGMVTTTILTLLVLPVVFTWAHRHGGVPPRE
PDVTPTAAMLP