Protein Info for RALBFv3_RS16150 in Ralstonia solanacearum IBSBF1503

Annotation: NAD-dependent succinate-semialdehyde dehydrogenase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• PF00171: Aldedh
  • amino acids 24 to 486 (463 residues), 551.7 bits, E=6e-170

Best Hits

KEGG orthology group: K00135, succinate-semialdehyde dehydrogenase (NADP+) [EC: 1.2.1.16] (inferred from 95% identity to rsl:RPSI07_mp1716)

MetaCyc: 40% identical to aldehyde dehydrogenase A (Escherichia coli K-12 substr. MG1655)
Lactaldehyde dehydrogenase. [EC: 1.2.1.22]; Glycolaldehyde dehydrogenase. [EC: 1.2.1.22, 1.2.1.21]

Predicted SEED Role

"Aldehyde dehydrogenase B (EC 1.2.1.22)" in subsystem Glycerolipid and Glycerophospholipid Metabolism in Bacteria or Methylglyoxal Metabolism (EC 1.2.1.22)

MetaCyc Pathways

• 4-aminobutanoate degradation III (2/2 steps found)
• superpathway of glycol metabolism and degradation (5/7 steps found)
• methylglyoxal degradation IV (2/3 steps found)
• methylglyoxal degradation V (2/3 steps found)
• L-lactaldehyde degradation (aerobic) (1/2 steps found)
• ethylene glycol degradation (1/2 steps found)
• superpathway of methylglyoxal degradation (5/8 steps found)
• lactate biosynthesis (archaea) (2/5 steps found)
• D-arabinose degradation II (1/4 steps found)
• L-rhamnose degradation II (2/8 steps found)
• superpathway of fucose and rhamnose degradation (3/12 steps found)
• superpathway of pentose and pentitol degradation (9/42 steps found)

KEGG Metabolic Maps

• Butanoate metabolism
• Glutamate metabolism
• Glyoxylate and dicarboxylate metabolism
• Pyruvate metabolism
• Tyrosine metabolism

Isozymes

Compare fitness of predicted isozymes for: 1.2.1.16, 1.2.1.22

Use Curated BLAST to search for 1.2.1.16 or 1.2.1.21 or 1.2.1.22

Protein Sequence (493 amino acids)

>RALBFv3_RS16150 NAD-dependent succinate-semialdehyde dehydrogenase (Ralstonia solanacearum IBSBF1503)
MAFTFDQLRQTGLIRTDNLIDGQWMGGADGERFAVTDPATGSIIAKVPDSSAADARAATD
AAARAFPAWRDALPAERAAILRRWHAGIVANADALGRLISLEQGKPFAEGRGEVLYGASY
VAWFADEATRIYGDLIPQQQRGKRMSAIKEPVGVVAAITPWNFPLAMIARKIAPALAAGC
TVVAKPAEDTPLTALALARLAQEAGLPPGVLNMISASRERGVAAVADWLQDSRVRKITFT
GSTPVGKYLVRESAGTLKKLSLELGGNAPFIVFDDADLDAAIAGLLAAKFRNGGQTCVCP
NRVYVQAGVYDRFAARLTERVSALKVAPASDPDAQIGPMINARAVDKIERHVQDAVAQGA
RVLAGGRRLPEVGAHFYAPTVLADANSRMALCGEETFGPVAPLFRFADEAEAVQAANDTP
FGLAAYFYSQDMRRIDRVSRALEAGIVGINEGALASEAAPFGGVKESGYGREGSKYGLDD
YLSIKYLCQGGLA