Protein Info for Psyr_2865 in Pseudomonas syringae pv. syringae B728a

Annotation: Hydrophobe/amphiphile efflux-1 HAE1

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 100 200 300 400 500 600 700 800 900 1048 signal peptide" amino acids 10 to 11 (2 residues), see Phobius details transmembrane" amino acids 12 to 28 (17 residues), see Phobius details amino acids 342 to 361 (20 residues), see Phobius details amino acids 368 to 390 (23 residues), see Phobius details amino acids 396 to 416 (21 residues), see Phobius details amino acids 441 to 462 (22 residues), see Phobius details amino acids 473 to 497 (25 residues), see Phobius details amino acids 543 to 560 (18 residues), see Phobius details amino acids 872 to 890 (19 residues), see Phobius details amino acids 897 to 917 (21 residues), see Phobius details amino acids 923 to 947 (25 residues), see Phobius details amino acids 971 to 991 (21 residues), see Phobius details amino acids 1000 to 1024 (25 residues), see Phobius details TIGR00915: RND transporter, hydrophobe/amphiphile efflux-1 (HAE1) family" amino acids 1 to 1040 (1040 residues), 1605.1 bits, see alignment E=0 PF00873: ACR_tran" amino acids 1 to 1026 (1026 residues), 1290.3 bits, see alignment E=0 PF03176: MMPL" amino acids 297 to 519 (223 residues), 36.9 bits, see alignment E=3.2e-13

Best Hits

Swiss-Prot: 60% identical to MEXB_PSEAE: Multidrug resistance protein MexB (mexB) from Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)

KEGG orthology group: K03296, hydrophobic/amphiphilic exporter-1 (mainly G- bacteria), HAE1 family (inferred from 60% identity to aex:Astex_3378)

MetaCyc: 60% identical to multidrug efflux pump RND permease AcrF (Escherichia coli K-12 substr. MG1655)
TRANS-RXN-352; TRANS-RXN-354; TRANS-RXN-355; TRANS-RXN-367

Predicted SEED Role

"RND efflux system, inner membrane transporter CmeB" in subsystem Multidrug Resistance Efflux Pumps or Multidrug efflux pump in Campylobacter jejuni (CmeABC operon)

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See Q4ZSH1 at UniProt or InterPro

Protein Sequence (1048 amino acids)

>Psyr_2865 Hydrophobe/amphiphile efflux-1 HAE1 (Pseudomonas syringae pv. syringae B728a)
MARFFIDRPIFAWVIAICIMFAGGLSISQLPLEQYPDIAPPTVKISATYTGASAKTVEDS
VTQVIEQQMKGLDRLTYMSASSSSAGSASISLTFAAGTDPDVAQMQVQNKLQQAESRLPQ
SVQSEGLTVTKGSSDFLMLVALASDNESVTGTQIGDYISSTLLDQLSRVDGVGDVQTLGS
GYAMRIWLDPARMEKYSLMPSDISSALEAQNTEVSAGQLGALPAVEGQQLNATISARSKL
QTPEQFENVVVKSSSDGAVVLLRDVARVELGSESYDINSALNGRPAAAMGIQLASGANAL
SVGEAIKAKLKELEPFYPAQMQLKTVIAYDTTPFVSLSIKEVVKSLGEAIVLVVLIMFLF
MQNLRATLIPAITVPVVLLGTFGVLALFGYSINTLTMFAMVLAIGLLVDDAIVVVENVER
VMDEEHLSPLEATRKSMDEITSALIGIALVLSAVFIPMAFFSGSTGIIYRQFSVTIVSAM
LLSVLVAMTLTPALCATMLKASDAQLHAKRGGFFGWFNRTFDRSADRYQRGVSGVIEHRV
KGLLVYALVLVVMAVGYVSLPTSFLPDEDQGALMAQIQLPVGATDSRTQAVMRQFEAYML
KQPEVEALISISGLGMGGNSQNTARAFIKLKDWSERSGKEQGAAQVAQRATLALASIGDA
SVFVMQPPAVRGLGQSSGFDVQLKDLGGVGHEALVAAREQFIELARKDSSMLGVRSNGLD
DTPQLKVTIDDRKAGALSLSTSDINSTLSTALGGSYINDFLNQGRVKKVYVQGEAASRMQ
SADLDHWFVRNSNDEMVPFSSFASSSWSYGSPLLERYNGSSSLEVVGDPAPGVSSGTAMD
AVEAIIKQLPEGIGYEWTGQSYQLRLSGSQAPMLYAISVLFVFLCLAALYESWSVPFSVM
LVVPLGVVGAVLATRISGLSNDVYFQVGLLTTVGLAAKNAILIVEFAKHLQEQGKSLHEA
TLLAARQRLRPILMTSLAFMFGVLPLALSSGAGSAGRNAIGTGVLGGMFSATVLGIFLVP
LFFVEVRRRFSRSSGNAPAAQPTSTGEA