Protein Info for Pf6N2E2_5872 in Pseudomonas fluorescens FW300-N2E2

Annotation: Sensor histidine kinase/response regulator

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 600 633 transmembrane" amino acids 15 to 35 (21 residues), see Phobius details amino acids 166 to 185 (20 residues), see Phobius details PF09984: sCache_4" amino acids 36 to 101 (66 residues), 31 bits, see alignment E=5.3e-11 PF00672: HAMP" amino acids 188 to 237 (50 residues), 39.4 bits, see alignment 1.5e-13 PF00512: HisKA" amino acids 264 to 327 (64 residues), 76.5 bits, see alignment E=3.3e-25 PF02518: HATPase_c" amino acids 377 to 492 (116 residues), 105.1 bits, see alignment E=7.2e-34 PF00072: Response_reg" amino acids 517 to 628 (112 residues), 91 bits, see alignment E=1.5e-29

Best Hits

KEGG orthology group: None (inferred from 99% identity to pba:PSEBR_a4122)

Predicted SEED Role

"Sensor histidine kinase/response regulator"

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A0A161GM39 at UniProt or InterPro

Protein Sequence (633 amino acids)

>Pf6N2E2_5872 Sensor histidine kinase/response regulator (Pseudomonas fluorescens FW300-N2E2)
MTLRRRWDINTRTQLIALGPALLLTVLLISFFTFVRIQDLRQELNHTGQLIANQLAPATE
YGVISGNKEVLESLLTATLATPHVRFLEVQDSTDKVLVYVEQPEQTRSHAQQVEVFQAPV
RLQRIALNNDFLQGNSPSVEASGEDYLGRVIVGMSSDAFSQRQQEILFKAAILALFALLF
TFLVARRLATNLSRPIRDIGNAVKAIQQGDYSTPLPIVDDAELGALSRHINNLAEGLGQA
SREQHQAMAQLIKTREEAEKANSAKSEFLAMMSHELRTPMNGVLGMLQLLETTRLTDEQH
EYTALASESTEHLLKVINDILDFSRIERSALELEHIPFNLAELVGSCAQSFQHSAAQRKL
GLDLLVPDDMQALQVQGDPTRIRQILVNLIGNALKFTEQGRVTVQCQWQALDHELLWFTC
TVRDSGIGIPAESLERMFDAFQQADNSISRRYGGTGLGLPIARTLAERMGGTLRAQSEEG
QGSVFTLEIPLALSRQTPPTLAPRLPTGSGDGEGRNVLLVEDNPVNQTVVEAMLRSLGFT
VSIATDGAQAVRSAESLIFEAILMDCRLPIIDGYEATRQIRQLPGCGEVPIIALTANALQ
GDREACLAAGMNDYLAKPFKRNDLQQILQRWVN