Protein Info for Pf6N2E2_3126 in Pseudomonas fluorescens FW300-N2E2

Annotation: 4-aminobutyraldehyde dehydrogenase (EC 1.2.1.19)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• PF00171: Aldedh
  • amino acids 27 to 477 (451 residues), 515.4 bits, E=5.9e-159

Best Hits

Swiss-Prot: 63% identical to ABDH_CITK8: Gamma-aminobutyraldehyde dehydrogenase (prr) from Citrobacter koseri (strain ATCC BAA-895 / CDC 4225-83 / SGSC4696)

KEGG orthology group: K00137, aminobutyraldehyde dehydrogenase [EC: 1.2.1.19] (inferred from 99% identity to pba:PSEBR_a1013)

MetaCyc: 63% identical to gamma-aminobutyraldehyde dehydrogenase (Escherichia coli K-12 substr. MG1655)
Aminobutyraldehyde dehydrogenase. [EC: 1.2.1.19]; 1.2.1.19 [EC: 1.2.1.19]

Predicted SEED Role

"4-aminobutyraldehyde dehydrogenase (EC 1.2.1.19)" in subsystem Polyamine Metabolism (EC 1.2.1.19)

MetaCyc Pathways

• superpathway of L-arginine and L-ornithine degradation (11/13 steps found)
• superpathway of ornithine degradation (7/8 steps found)
• superpathway of L-arginine, putrescine, and 4-aminobutanoate degradation (9/11 steps found)
• L-lysine degradation X (5/6 steps found)
• putrescine degradation V (2/2 steps found)
• putrescine degradation IV (2/3 steps found)
• putrescine degradation I (1/2 steps found)
• L-lysine degradation I (4/7 steps found)
• superpathway of L-lysine degradation (19/43 steps found)

KEGG Metabolic Maps

• Arginine and proline metabolism
• Urea cycle and metabolism of amino groups
• beta-Alanine metabolism

Isozymes

Compare fitness of predicted isozymes for: 1.2.1.19

Use Curated BLAST to search for 1.2.1.19

Sequence Analysis Tools

See A0A160A105 at UniProt or InterPro

Protein Sequence (485 amino acids)

>Pf6N2E2_3126 4-aminobutyraldehyde dehydrogenase (EC 1.2.1.19) (Pseudomonas fluorescens FW300-N2E2)
MAGMQTPLCTALLIDGELVPGAGIVEPILNPATGEVVAHIAEASTEQVEAAILAAHRAFD
GWSRTTPQQRSNLLLDIASAIEKNADELARLESLNCGKPLYLARQDDLSATVDVFRFFAG
AVRCQTGQLSGEYLPGYTSMVRRDPIGVVASIAPWNYPIMMAAWKIAPALAAGNTLVFKP
SEHTPLSILALAPTLAQILPRGVINILCGGGEGVGSHLVSHPKVRMVSLTGDIVTGQKIL
QAAAKTLKRTHLELGGKAPVIVCNDADIQAVVEGVRTYGYYNAGQDCTAACRIYAQGAIH
DRLVAELGAAVSSLRFAGKRDADNEIGPLISTRQRDRVASFVERALGQPHIERITGAAVH
SGAGFYYQPTLLAGCKQSDEIVQREVFGPVVTVTRFDELSQAVDWANDSEYGLASSVWTQ
NLDKAMQVAARLQYGCTWINSHFMLVSEMPHGGLKRSGYGKDLSSDSLQDYSVVRHIMAR
HGQHL