Protein Info for Pf6N2E2_3119 in Pseudomonas fluorescens FW300-N2E2

Annotation: Sensor histidine kinase/response regulator

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 600 650 700 754 PF01627: Hpt" amino acids 11 to 96 (86 residues), 45.8 bits, see alignment E=1.2e-15 PF02518: HATPase_c" amino acids 335 to 473 (139 residues), 43.6 bits, see alignment E=7.5e-15 PF01584: CheW" amino acids 480 to 607 (128 residues), 69.6 bits, see alignment E=4.2e-23 PF00072: Response_reg" amino acids 633 to 745 (113 residues), 88.7 bits, see alignment E=5.8e-29

Best Hits

KEGG orthology group: K13490, two-component system, chemotaxis family, sensor histidine kinase and response regulator WspE (inferred from 98% identity to pba:PSEBR_a1020)

Predicted SEED Role

"Sensor histidine kinase/response regulator"

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A0A159ZZU4 at UniProt or InterPro

Protein Sequence (754 amino acids)

>Pf6N2E2_3119 Sensor histidine kinase/response regulator (Pseudomonas fluorescens FW300-N2E2)
MTPDQMRDASLLELFSLEAEAQVQVLSAGLLALERDPTQADYLESCMRAAHSLKGAARIV
GVDAGVSVAHVMEDCLVSAQEQRLVLGAEHIDALLQGTDLLMRIATPGNSVGAPDIDAYV
ALMGRLLDPNAPQAPAVVLPSVETAVEPLRIELPDVEPPPATEPAPQRKRVTEGGERVLR
VTAERLNSLLDLSSKSLVETQRLKPWLATMQRLKRQQSTGLRALEELNVHLKDHALSLQA
QEALGDARRLLAETQQLLAQKTAELDEFAWQASQRAQVLYDTALACRMRPFADVLSGQAR
MVRDLGRSLDKQVRLEIEGEKTQVDRDVLEKLEAPLTHLLRNAVDHGIEPPEQRILAGKP
AEGVIRLRASHQAGLLVLELADDGAGVDLERVRRSIVERGLSPEQTAASLSEEELLTFLF
LPGFSLRDKVTEVSGRGVGLDAVQHMVRQLRGAVVLEQTAGEGSRFHLEVPLTLSVVRSL
VVEVGDEAYAFPLAHIERMCDLAPEDIVQVEGRQHFWHEGRHIGLVAASQLLNRPATQGS
NQTLKVVVIRERETIYGVAVERFIGERTLVVLPLDERLGKVQDISAGALLDDGSVVLIVD
VEDLLRSVDKLLDTGRLERIARQNQAQAPRKRILVVDDSLTVRELQRKLLLNRGYDVAVA
VDGMDGWNALRSEDFDLLITDIDMPRMDGIELVSLLRRDNRLQSLPVMVVSYKDREEDRR
RGLDAGADYYLAKASFHDDALLDAVVELIGGARA