Protein Info for MPMX20_04145 in Enterobacter sp. TBS_079

Annotation: Glutarate-semialdehyde dehydrogenase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• PF00171: Aldedh
  • amino acids 27 to 478 (452 residues), 566.2 bits, E=2.4e-174
• TIGR01780: succinate-semialdehyde dehydrogenase
  • amino acids 31 to 477 (447 residues), 662.3 bits, E=1.9e-203

Best Hits

Swiss-Prot: 59% identical to DAVD_PSEPK: Glutarate-semialdehyde dehydrogenase (davD) from Pseudomonas putida (strain ATCC 47054 / DSM 6125 / NCIMB 11950 / KT2440)

KEGG orthology group: K00135, succinate-semialdehyde dehydrogenase (NADP+) [EC: 1.2.1.16] (inferred from 96% identity to enc:ECL_04622)

MetaCyc: 58% identical to NAD(P)-dependent succinate-semialdehyde dehydrogenase (Pseudomonas fluorescens)
Succinate-semialdehyde dehydrogenase (NAD(P)(+)). [EC: 1.2.1.16]

Predicted SEED Role

"Aldehyde dehydrogenase B (EC 1.2.1.22)" in subsystem Glycerolipid and Glycerophospholipid Metabolism in Bacteria or Methylglyoxal Metabolism (EC 1.2.1.22)

MetaCyc Pathways

• superpathway of methylglyoxal degradation (7/8 steps found)
• methylglyoxal degradation IV (3/3 steps found)
• methylglyoxal degradation V (3/3 steps found)
• 4-aminobutanoate degradation III (2/2 steps found)
• L-lactaldehyde degradation (aerobic) (2/2 steps found)
• superpathway of fucose and rhamnose degradation (8/12 steps found)
• lactate biosynthesis (archaea) (2/5 steps found)
• L-rhamnose degradation II (2/8 steps found)

KEGG Metabolic Maps

• Butanoate metabolism
• Glutamate metabolism
• Pyruvate metabolism
• Tyrosine metabolism

Isozymes

Compare fitness of predicted isozymes for: 1.2.1.16, 1.2.1.22

Use Curated BLAST to search for 1.2.1.16 or 1.2.1.22

Protein Sequence (484 amino acids)

>MPMX20_04145 Glutarate-semialdehyde dehydrogenase (Enterobacter sp. TBS_079)
MTTQALQDNHLFQTGYLVNGIWKTLDTTFDVLNPATGEVIARVAKAGKAETEDAIAAAAK
AFPAWRAKTAKARSAILYRWYELIIENKSWLGRLMTTEQGKPLKEAEGEVEYAASFIQWF
AEEAKRANGEIIPPIKPGSRILATREPIGVVAAITPWNFPMAMLTRKLGPALAAGCTGVI
KPANNTPLSAFALLTLAKQAGVPDGVLNAVAGNTHEISDAIMASHEVRKISFTGSTSVGK
TLVRNAAETMKKVSMELGGNAPYIVFEDADIEAAVKGAIANKFRNAGQVCVSVNRFYIQE
TVYDKFVNKLADAVKALKVGNGLEEGVIVGPLIESSAVDKVREHVEDAVARGATVLAGGK
PHSLGGNFWMPTVLGDCHEGMKLAEEETFGPVAACFRFTSEDEVIQRANNTPYGLAAYFY
TQNLARVFRVSQAIESGMIGINECAVSTELGPFGGVKESGLGREGSVLGLEEYLEVKTLH
IGGL