Protein Info for MPMX20_03398 in Enterobacter sp. TBS_079

Annotation: Alpha-2-macroglobulin

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 100 200 300 400 500 600 700 800 900 1000 1100 1200 1300 1400 1500 1600 1650 signal peptide" amino acids 1 to 23 (23 residues), see Phobius details PF17970: bMG1" amino acids 57 to 161 (105 residues), 161 bits, see alignment 4.2e-51 PF21142: A2M_bMG2" amino acids 167 to 285 (119 residues), 171.5 bits, see alignment 3.5e-54 PF11974: bMG3" amino acids 287 to 380 (94 residues), 82.8 bits, see alignment 8.7e-27 PF01835: MG2" amino acids 386 to 477 (92 residues), 71.8 bits, see alignment 2.8e-23 PF17972: bMG5" amino acids 483 to 608 (126 residues), 133.5 bits, see alignment 3.3e-42 PF17962: bMG6" amino acids 637 to 739 (103 residues), 87.1 bits, see alignment 5.4e-28 PF07703: A2M_BRD" amino acids 757 to 904 (148 residues), 67.6 bits, see alignment E=8.1e-22 PF00207: A2M" amino acids 973 to 1054 (82 residues), 31 bits, see alignment 1e-10 PF07678: TED_complement" amino acids 1174 to 1288 (115 residues), 34.8 bits, see alignment 5.2e-12 PF21765: A2MG_CUB" amino acids 1440 to 1501 (62 residues), 93.1 bits, see alignment (E = 6.5e-30) PF17973: bMG10" amino acids 1502 to 1635 (134 residues), 84.9 bits, see alignment E=3e-27

Best Hits

Swiss-Prot: 78% identical to A2MG_ECOLI: Alpha-2-macroglobulin (yfhM) from Escherichia coli (strain K12)

KEGG orthology group: K06894, (no description) (inferred from 95% identity to enc:ECL_03866)

Predicted SEED Role

"Alpha-2-macroglobulin"

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (1650 amino acids)

>MPMX20_03398 Alpha-2-macroglobulin (Enterobacter sp. TBS_079)
MTPFRLAAISLALLTTFSLVGCDNSDDNSQVAAPAASTATTPKAPEKPDAEKLATLAAQS
QGKALTLLDTSEVQLDGAATLVLTFSVPLNPDQDFAKTVHVVDKKSGKVDGAWELAPNLK
ELRLRHLEPNRNLVVTVERDLQALNKATFGIDYEKALTTRDVEPTVGFASRGSLLPGKVV
EGLPVMALNVNNVDVNFYRVKPESLASFVSQWEYRNSLTNWESDNLLKMADLVYTGRFDL
NPARNTREKLLLPLRDIKPLQQSGVYIAVMNQAGHYNYSNAATLFTLSDIGLSAHRYHNR
LDIFTQSLEDGAAQSGVTVTLLNDKGQTLAEANSDADGHAKLETDKEAALILASKDGQTT
LLDLKLPALDLAEFDIAGNPGYSKQFFMFGPRDLYRPGETVILNGLLRDSDGKPLPAQPV
KLDVLRPDGQVARTVVVQPENGLYRFNYSLDGGAQTGMWHIRANTGDNQQRLWDFHVEDF
MPERMALNLTGQKVPVSTEDNVDFNIAGYYLYGAPANGNSLQGQLFLRPLREAVAALPGF
QFGDIAEENLSRSLDEVQLTLDEQGRGQVSTESQWKEAHSPLQLILQASLLESGGRPVTR
RAEQAIWPAAELPGIRPQFASKAVYDYRTDTTVNQPIVDENGNASFDIVYADASGAKKAV
SGLQVRLIRERRDYYWNWSESDGWQSQFDQKDLVEGEQELTLKADETGKVTFPVEWGSYR
LEVKAPDDMVSSVRFWAGYSWQDNSDGTGAARPDRVTMKLDKPSYQPGDTIQLHIAAPAA
GKGYAMIESSEGPLWWKEIDVPANGLDLSIPVDKAWKRHDLYLSTLVVRPGDKSKSATPK
RAVGLLHLPMGDENRRLNVALENPQKMRPNQTLSVKVKASVKDGAVPQKVNVLISAVDSG
VLNITDYVTPDPWEAFFGQKRYGADIYDIYGQVIEGQGRMAALRFGGDGDELKRGGKPPV
NHVTIIAQQAQPIELDANGEGTVTLPIGDFNGELRLMAQAWTEDDFGSSEGKVIVAAPII
TELNTPRFLASGDTSRLTLDVTNLTDQPQTLNVAFTATGKLSLEGAQPQPVKLPPGARST
LFIPVRALDGYGDGEVTAQVTGLQLPGETFAAQQKSWKIGVRPAFPAQTVNTGAMLNPGE
SWSAPAQHLNGFSPATLQGQLLLSGKPPLNLARYIRELQAYPYGCLEQTTSGLFPSLYTN
AAQLTALGIKGDTDDKRRAAIDIGISRLLQMQRDDGGFALWDKNGPEEYWLTAYVTDFLV
RAGEQGYSVPAEAVNNANSRLLRYLQDPGMMSIRYSDDTQASKFAVQAYAALVLARQQKA
PLGALREIWERHGQAASGLPLMQLGMALKLMGDAPRSQQALGLAIKTPRNDSKNWMADYG
SALRDNALMLSLLEEYKLLPDAQNTLLNALSEQAFSQRWLSTQESNALFLAGRSLQTLSG
AWQAQTSLADTASGGDKALVQNVNGDQLGALQVTNTGSTPLWVRLDSTGYPASAPQPSSN
VLQIERHILATDGSTKSLTSLKSGELVLVWLEVKASQNVPDALVVDLLPAGLELENQNLA
SSSASLQDSGSEVQNLLSQMQQADIQHMEFRDDRFVAAVPVNEGQPVTLVYLARAVTPGT
YEVPVPMVESMYVPQWRATGAASGPLIVVP