Protein Info for MPMX20_03107 in Enterobacter sp. TBS_079

Annotation: Antibiotic efflux pump outer membrane protein ArpC

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 469 signal peptide" amino acids 1 to 23 (23 residues), see Phobius details TIGR01845: efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family" amino acids 29 to 465 (437 residues), 266.4 bits, see alignment E=2.4e-83 PF02321: OEP" amino acids 59 to 258 (200 residues), 61.6 bits, see alignment E=4.4e-21 amino acids 284 to 463 (180 residues), 54.9 bits, see alignment E=5.1e-19

Best Hits

Swiss-Prot: 68% identical to MDTQ_ECO57: Multidrug resistance outer membrane protein MdtQ (mdtQ) from Escherichia coli O157:H7

KEGG orthology group: None (inferred from 86% identity to enc:ECL_03450)

Predicted SEED Role

"RND efflux system, outer membrane lipoprotein, NodT family" in subsystem Multidrug Resistance Efflux Pumps

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (469 amino acids)

>MPMX20_03107 Antibiotic efflux pump outer membrane protein ArpC (Enterobacter sp. TBS_079)
MKPLSLSIPLVFILVACAPEHASVSPVNMQSTTAAVNTTLSHTAWPKDAWWKTYNDPELN
SLIAKALNDAPDMQIARQRITLAEAQAKATLAAGGPEIDFSADAERQKMSAEGLMGPFAI
TDPAAGTTGPWYTNGTFGLSAGWDLDLWGKNRARVEARIGRVNAQKAELEQTRQLLASSV
ARLYWAWQTQAAVGDVLTEIKHQQDTIIAADRELYQHGITSSVEGVETDINASKTDEQLA
EVNGKMKAVEARLSALTNTSSVTLTRHALPTVEASLPATLGYELLARRPDLQEARWYIEA
SMSDVEAARAAFYPDVNLMAFLQQDALHLSDLFRSSAQQRGVTAGLTLPIFDSGRLNAEL
DIAQAQNNLSVARYNKAVVDAVNQVARTASEVETLTAKNQHQQRVEKEAARVVALAQARF
RAGIIAGSRVSEARIPALREQLTGVMLKGQYVDATLQLTSALGGGYHQG