Protein Info for MPMX20_02488 in Enterobacter sp. TBS_079

Annotation: Cyclic di-GMP phosphodiesterase PdeR

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 600 663 TIGR00229: PAS domain S-box protein" amino acids 115 to 233 (119 residues), 53.7 bits, see alignment E=2.3e-18 PF00989: PAS" amino acids 115 to 222 (108 residues), 32.5 bits, see alignment E=1.5e-11 PF13426: PAS_9" amino acids 124 to 225 (102 residues), 39 bits, see alignment E=1.7e-13 TIGR00254: diguanylate cyclase (GGDEF) domain" amino acids 234 to 394 (161 residues), 121.5 bits, see alignment E=2.9e-39 PF00990: GGDEF" amino acids 237 to 390 (154 residues), 152.5 bits, see alignment E=1.8e-48 PF00563: EAL" amino acids 412 to 644 (233 residues), 227.5 bits, see alignment E=3.2e-71

Best Hits

Swiss-Prot: 79% identical to PDER_ECOLI: Cyclic di-GMP phosphodiesterase PdeR (pdeR) from Escherichia coli (strain K12)

KEGG orthology group: K14051, cyclic di-GMP phosphodiesterase Gmr [EC: 3.1.4.52] (inferred from 98% identity to enc:ECL_01754)

MetaCyc: 79% identical to cyclic di-GMP phosphodiesterase PdeR (Escherichia coli K-12 substr. MG1655)
Cyclic-guanylate-specific phosphodiesterase. [EC: 3.1.4.52]

Predicted SEED Role

"FIG00626766: hypothetical protein"

Isozymes

No predicted isozymes

Use Curated BLAST to search for 3.1.4.52

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (663 amino acids)

>MPMX20_02488 Cyclic di-GMP phosphodiesterase PdeR (Enterobacter sp. TBS_079)
MMDDLEQNLLFRYMGTHSPWWRMTADSNALHLAASENTDVTEVVALDDEQAELIRQLTVI
TSSISMTLSLYGEDVPVHLVGRKITRNEWAGTASAWNDTPSVARDLAQGLSFAEQVVSEA
NSVIVILDHNGNIQRFNRLSEEYTGLKEQEVIGQNVFKLFMSRSEAAASKRNITGFFRNG
SSYEVERWIKTRKGQRLFLFRNKFVHSGSGKNEIFLICSGTDITEERRAQERLRVLANTD
TITGLPNRNAIHELISDAIASRGETQVGVVYLDLDNFKKVNDAYGHMFGDQLLQAVALAI
LSCLDDGQVLARLGGDEFIVMATDTSQGSLEAMASRILTRLRQPFRIGLIEIYTGCSLGI
ALAPQHGNDRESVIRNADTAMYTAKENGRGKFCVFSPEMNQRVFEYLWLDTNLRKALDND
QLLIHYQPKITWRGEIRSLEALVRWQSPERGLIPPLEFISYAEESGLIVPLGRWVMLDVV
RQVAKWRDKGINLRVAVNVSARQLADQTIFSDLKQALKDLDFEYCPIDVELTESCLIENE
ELALSVIQQFSKLGAQIHLDDFGTGYSSLSQLARFPIDAIKLDQSFVRDIHKQSISQSLV
RAIVAVAQALNLQVIAEGVESAKEDAFLTKNGVNERQGFLFAKPMPAAAFERWLKRYQSR
KQR