Protein Info for MPMX20_02420 in Enterobacter sp. TBS_079

Annotation: Gamma-aminobutyraldehyde dehydrogenase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• TIGR03374: 1-pyrroline dehydrogenase
  • amino acids 2 to 473 (472 residues), 998.3 bits, E=2.6e-305
• PF00171: Aldedh
  • amino acids 13 to 470 (458 residues), 560.1 bits, E=1.7e-172

Best Hits

Swiss-Prot: 92% identical to ABDH_ENT38: Gamma-aminobutyraldehyde dehydrogenase (prr) from Enterobacter sp. (strain 638)

KEGG orthology group: K00137, aminobutyraldehyde dehydrogenase [EC: 1.2.1.19] (inferred from 96% identity to enc:ECL_01853)

MetaCyc: 87% identical to gamma-aminobutyraldehyde dehydrogenase (Escherichia coli K-12 substr. MG1655)
Aminobutyraldehyde dehydrogenase. [EC: 1.2.1.19]; 1.2.1.19 [EC: 1.2.1.19]

Predicted SEED Role

"4-aminobutyraldehyde dehydrogenase (EC 1.2.1.19)" in subsystem Polyamine Metabolism (EC 1.2.1.19)

MetaCyc Pathways

• L-lysine degradation X (5/6 steps found)
• putrescine degradation I (2/2 steps found)
• L-lysine degradation I (5/7 steps found)
• putrescine degradation IV (2/3 steps found)
• putrescine degradation V (1/2 steps found)
• superpathway of L-arginine and L-ornithine degradation (8/13 steps found)
• superpathway of ornithine degradation (4/8 steps found)
• superpathway of L-arginine, putrescine, and 4-aminobutanoate degradation (6/11 steps found)
• superpathway of L-lysine degradation (12/43 steps found)

KEGG Metabolic Maps

• Arginine and proline metabolism
• Urea cycle and metabolism of amino groups
• beta-Alanine metabolism

Isozymes

No predicted isozymes

Use Curated BLAST to search for 1.2.1.19

Protein Sequence (474 amino acids)

>MPMX20_02420 Gamma-aminobutyraldehyde dehydrogenase (Enterobacter sp. TBS_079)
MQTQLLINGELVAGDGEKQPVYNPATGEVLLEIAEASAAQVDAAVRAADRAFIEWGQTTP
KTRAECLLKLADVIEAHGEEFARLESLNCGKPLHCALGDEIPAVVDVFRFFAGAARCLNG
LAAGEYLDGHTSMIRRDPVGVVASIAPWNYPLMMAAWKLAPALAAGNCVVIKPSEITPLT
ALKLAELAKDIFPAGVLNVLFGRGKTVGDPLTGHEKVRMVSLTGSIATGEHIIGHTASSI
KRTHMELGGKAPVIVFDDADLDAVVEGVRTFGFYNAGQDCTAACRIYAQKGVYAALVEKL
GAAVASLKMGAPEEETTELGPLSSEAHLSRVCKAVDEAKALSHIRVVTGGSKKEGAGYYF
QPTLLAGAKQDDAIVQREVFGPVVSVTEFDDEAQVLAWANDSQYGLASSVWTRDVGRAHR
MSARLQYGCTWVNTHFMLVSEMPHGGMKLSGYGKDMSVYGLEDYTVVRHVMIKL