Protein Info for MPMX20_01487 in Enterobacter sp. TBS_079

Annotation: Arsenical pump membrane protein

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 429 signal peptide" amino acids 1 to 36 (36 residues), see Phobius details transmembrane" amino acids 51 to 70 (20 residues), see Phobius details amino acids 91 to 109 (19 residues), see Phobius details amino acids 115 to 131 (17 residues), see Phobius details amino acids 138 to 160 (23 residues), see Phobius details amino acids 176 to 198 (23 residues), see Phobius details amino acids 218 to 240 (23 residues), see Phobius details amino acids 246 to 263 (18 residues), see Phobius details amino acids 275 to 296 (22 residues), see Phobius details amino acids 312 to 333 (22 residues), see Phobius details amino acids 401 to 425 (25 residues), see Phobius details TIGR00935: arsenite/antimonite efflux pump membrane protein" amino acids 2 to 426 (425 residues), 724.8 bits, see alignment E=2.1e-222 PF02040: ArsB" amino acids 3 to 423 (421 residues), 528.3 bits, see alignment E=2.1e-162 PF03600: CitMHS" amino acids 12 to 368 (357 residues), 201.1 bits, see alignment E=2.7e-63

Best Hits

Swiss-Prot: 90% identical to ARSB2_ECOLX: Arsenical pump membrane protein (arsB) from Escherichia coli

KEGG orthology group: None (inferred from 95% identity to enc:ECL_02870)

MetaCyc: 88% identical to arsenous acid/antimonous acid:H+ antiporter ArsB (Escherichia coli)
RXN-22366 [EC: 7.3.2.7]; 7.3.2.7 [EC: 7.3.2.7]; RXN-22385 [EC: 7.3.2.7]; RXN3O-9786 [EC: 7.3.2.7]

Predicted SEED Role

"Arsenic efflux pump protein" in subsystem Arsenic resistance

MetaCyc Pathways

Isozymes

No predicted isozymes

Use Curated BLAST to search for 7.3.2.7

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (429 amino acids)

>MPMX20_01487 Arsenical pump membrane protein (Enterobacter sp. TBS_079)
MFLAGAIFLFTLVLVIWQPRGLSIGWSATIGAVLALASGVIHINDIPVVWNIVWNATATF
IAVIIISLLLDESGFFEWAALHVARWGNGKGRLLFTYIVLLGAAVAALFANDGAALILTP
IVIAMLLALGFSKQATLAFVMAAGFIADTASLPLIVSNLVNIVSADFFSLGFSEYASVMI
PVDLAAIAATLVMLHLFFRKDIPPTYDLSKLREPSRAINDLPTFRTGWIVLLLLLVGFFV
LEPLGIPVSAIATAGALILFAVAKRGHAINTGKVLRGAPWQIVIFSLGMYLVVYGLRNAG
LTEYLSGVLNLLAGHGLWATTLGTGFITAFLSSIMNNMPTVLIGALSVDGSTASGVIKDA
MIYANVIGCDLGPKITPIGSLATLLWLHVLAQKNMTITWGYYFRTGIIMTLPVLFVTLAA
LALRLSFTL