Protein Info for MPMX20_00539 in Enterobacter sp. TBS_079

Annotation: HTH-type transcriptional regulator TreR

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 315 TIGR02405: trehalose operon repressor" amino acids 4 to 314 (311 residues), 551.4 bits, see alignment E=3.1e-170 PF00356: LacI" amino acids 6 to 51 (46 residues), 74.5 bits, see alignment 7e-25 PF00532: Peripla_BP_1" amino acids 83 to 314 (232 residues), 43.4 bits, see alignment E=4.7e-15 PF13377: Peripla_BP_3" amino acids 168 to 314 (147 residues), 70.3 bits, see alignment E=3.3e-23

Best Hits

Swiss-Prot: 86% identical to TRER_ECOLI: HTH-type transcriptional regulator TreR (treR) from Escherichia coli (strain K12)

KEGG orthology group: K03485, LacI family transcriptional regulator, trehalose operon repressor (inferred from 96% identity to enc:ECL_00659)

Predicted SEED Role

"Trehalose operon transcriptional repressor" in subsystem Trehalose Uptake and Utilization

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (315 amino acids)

>MPMX20_00539 HTH-type transcriptional regulator TreR (Enterobacter sp. TBS_079)
MQNRLTIKDIARLSGVGKSTVSRVLNNESGVSERTRERVEAVMNQHGFSPSRSARAMRGQ
SDKVVAIIVSRLDSLSENLAVQTMLPAFYEQGYDPIMMESQFSTQLVEEHLGMLQRRNID
GVVLFGFTGIKEEMLKPWQASMVMLARDAHGFASVCYDDEGAIITLMQRLYDKGHRHISY
LGVPHADVTTGKRRHEAYLTFCKQHNLSAVASLPGLGMKQGYEQVASVLTPQTTALVCAT
DTLALGASKYLQEQRIEGLQIASVGSTPLMKFLHPEIITVDPGYAESGRQAAAQLIEQIN
GRAEPRQIVIPAHLS