Protein Info for MPMX20_00421 in Enterobacter sp. TBS_079

Annotation: L-methionine/branched-chain amino acid exporter YjeH

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 412 signal peptide" amino acids 1 to 34 (34 residues), see Phobius details transmembrane" amino acids 43 to 63 (21 residues), see Phobius details amino acids 88 to 110 (23 residues), see Phobius details amino acids 121 to 137 (17 residues), see Phobius details amino acids 146 to 165 (20 residues), see Phobius details amino acids 186 to 208 (23 residues), see Phobius details amino acids 220 to 245 (26 residues), see Phobius details amino acids 267 to 287 (21 residues), see Phobius details amino acids 315 to 337 (23 residues), see Phobius details amino acids 343 to 363 (21 residues), see Phobius details amino acids 373 to 405 (33 residues), see Phobius details PF13520: AA_permease_2" amino acids 12 to 390 (379 residues), 102 bits, see alignment E=3.7e-33 PF00324: AA_permease" amino acids 21 to 407 (387 residues), 35.2 bits, see alignment E=6.1e-13

Best Hits

Swiss-Prot: 82% identical to YJEH_ECOLI: L-methionine/branched-chain amino acid exporter YjeH (yjeH) from Escherichia coli (strain K12)

KEGG orthology group: K03294, basic amino acid/polyamine antiporter, APA family (inferred from 90% identity to enc:ECL_00539)

MetaCyc: 82% identical to L-methionine/branched chain amino acid exporter (Escherichia coli K-12 substr. MG1655)
RXN0-7050; TRANS-RXN-281; TRANS-RXN-282; TRANS-RXN0-270

Predicted SEED Role

"Putative permease"

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (412 amino acids)

>MPMX20_00421 L-methionine/branched-chain amino acid exporter YjeH (Enterobacter sp. TBS_079)
MSGLKQELGLAQGVGLLSTSLLGTGVFAVPALAALVAGNNSLWAWPVLIVLVFPVAVVFA
ILGRHFPSAGGVAHFVGMAFGPRLERVTGWLFLSVIPVGLPAALHIATGFGQALFGWHNE
QLLLAELGTLAIVWWVGSRGASSSANLQTVVAILIVALIVAIWWKGDITLKEIPFPTVSE
VNHSQLFAALSVMFWCFVGLEAFAHLASEFKQPERDFPRALMIGLLLAGTVYWACTVLVL
HFNAFAADKAAAASLPGIVVQLFGLKALWVACVIGYLACFASLNIYIQSFARLVWSQALD
KPESRLARLSKRQLPLNALNTVLGCCVLSSLCIYGLNINLDALIVYANGIFIMIYLLCML
AGCRLLKGRYKALAVVGGVLCLLLMAMVGWKSLYAISMLAGLWLFLPKRGTL