Protein Info for MPMX20_00416 in Enterobacter sp. TBS_079

Annotation: Thiol:disulfide interchange protein DsbD

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 567 signal peptide" amino acids 1 to 20 (20 residues), see Phobius details transmembrane" amino acids 170 to 197 (28 residues), see Phobius details amino acids 210 to 234 (25 residues), see Phobius details amino acids 246 to 270 (25 residues), see Phobius details amino acids 291 to 320 (30 residues), see Phobius details amino acids 332 to 354 (23 residues), see Phobius details amino acids 366 to 384 (19 residues), see Phobius details amino acids 390 to 411 (22 residues), see Phobius details amino acids 418 to 435 (18 residues), see Phobius details PF11412: DsbD_N" amino acids 29 to 138 (110 residues), 123.5 bits, see alignment E=1.5e-39 PF13386: DsbD_2" amino acids 173 to 361 (189 residues), 36 bits, see alignment E=2.2e-12 PF02683: DsbD" amino acids 174 to 379 (206 residues), 69.5 bits, see alignment E=1.1e-22 PF13899: Thioredoxin_7" amino acids 464 to 538 (75 residues), 47.8 bits, see alignment E=4e-16 PF13098: Thioredoxin_2" amino acids 466 to 562 (97 residues), 49.7 bits, see alignment E=1.2e-16

Best Hits

Swiss-Prot: 81% identical to DSBD_SALPA: Thiol:disulfide interchange protein DsbD (dsbD) from Salmonella paratyphi A (strain ATCC 9150 / SARB42)

KEGG orthology group: K04084, thiol:disulfide interchange protein DsbD [EC: 1.8.1.8] (inferred from 88% identity to enc:ECL_00534)

MetaCyc: 82% identical to thiol-disulfide exchange protein DsbD (Escherichia coli K-12 substr. MG1655)
RXN-19949 [EC: 1.8.4.16]; 1.8.4.16 [EC: 1.8.4.16]; 1.8.4.16 [EC: 1.8.4.16]; RXN0-7311 [EC: 1.8.4.16]

Predicted SEED Role

"Cytochrome c-type biogenesis protein DsbD, protein-disulfide reductase (EC 1.8.1.8)" in subsystem Biogenesis of c-type cytochromes or Periplasmic disulfide interchange (EC 1.8.1.8)

MetaCyc Pathways

Isozymes

Compare fitness of predicted isozymes for: 1.8.1.8

Use Curated BLAST to search for 1.8.1.8 or 1.8.4.16

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (567 amino acids)

>MPMX20_00416 Thiol:disulfide interchange protein DsbD (Enterobacter sp. TBS_079)
MAQRFLTLILLLCSTSVFAGLFDAPGRSNVISADQAFVFDFQQDQHDLNLTWQIKEGYYL
YRKQVSITPAQAKVGPLQMPAGEWHEDEFFGKSEIYRQRLSVPVAVNQADKGATVTVTYQ
GCADAGFCYPPETKVIPLSEVKAAASMPALPAGESTGVKDDGHTALPFSALWALLIGIGI
AFTPCVLPMSPLISGIVLGGKQRLSTARALLLAFIYVQGMALTYTALGLVVAAAGLQFQA
ALQHPYVLTGLSIVFIVLALSMFGLFSLQLPSALQTRLTLMSNRQQGGSPGGVFVMGAIA
GLICSPCTTAPLSAILLYIAQSGNLWLGGGTLYLYALGMGLPLILVTVFGNRLLPKSGPW
METVKTAFGFVILALPVFLLERIIGDVWGMRLWAMLSVAFFCWAFITSLAAKKPWMRLVQ
ILLLAAALVSVRPLQDWAFGTPAGQTQAHLNFIQIKNVDELNSALAQAEGKPVMLDLYAD
WCVACKEFEKYTFSDPQVQSALKETVLLQANVTANSTADKALLKQLNVLGLPTILFFNEQ
GQEQPAQRVTGFMDATAFSAHLRNRQP