Protein Info for MPMX20_00034 in Enterobacter sp. TBS_079

Annotation: Signal transduction histidine-protein kinase/phosphatase UhpB

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 501 transmembrane" amino acids 6 to 28 (23 residues), see Phobius details amino acids 38 to 60 (23 residues), see Phobius details amino acids 80 to 100 (21 residues), see Phobius details amino acids 112 to 130 (19 residues), see Phobius details amino acids 137 to 161 (25 residues), see Phobius details amino acids 184 to 202 (19 residues), see Phobius details amino acids 208 to 225 (18 residues), see Phobius details amino acids 230 to 248 (19 residues), see Phobius details amino acids 254 to 272 (19 residues), see Phobius details PF05231: MASE1" amino acids 15 to 273 (259 residues), 50.8 bits, see alignment E=2.1e-17 PF07730: HisKA_3" amino acids 304 to 369 (66 residues), 53.7 bits, see alignment E=3.7e-18 PF02518: HATPase_c" amino acids 409 to 497 (89 residues), 49.5 bits, see alignment E=8e-17

Best Hits

Swiss-Prot: 89% identical to UHPB_SALTY: Signal transduction histidine-protein kinase/phosphatase UhpB (uhpB) from Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)

KEGG orthology group: K07675, two-component system, NarL family, sensor histidine kinase UhpB [EC: 2.7.13.3] (inferred from 95% identity to enc:ECL_00037)

MetaCyc: 86% identical to sensor histidine kinase UhpB (Escherichia coli K-12 substr. MG1655)
Histidine kinase. [EC: 2.7.13.3]

Predicted SEED Role

"Sensor histidine protein kinase UhpB, glucose-6-phosphate specific (EC 2.7.13.3)" in subsystem Hexose Phosphate Uptake System (EC 2.7.13.3)

Isozymes

Compare fitness of predicted isozymes for: 2.7.13.3

Use Curated BLAST to search for 2.7.13.3

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (501 amino acids)

>MPMX20_00034 Signal transduction histidine-protein kinase/phosphatase UhpB (Enterobacter sp. TBS_079)
MNPLFSRLIAVAASFSIFSAAWFCLWSISLHLVERPELAVLLFPFGLRLGLMLQCPRGFW
PVLLGAEWLMLVWLAQEVALAHLPLLVTGSVLTLIPVALISRYRHQRDWRTLLRQGAALI
AAALLQSLPWTGEEEMLNALLLTLTGGLTLAPTCLVIWHYLTSTVWQPLGPALVSQPVNW
RARHLIWYLLLFAISLWLQLGLPDELSRFTPFCLALPIIALAWHYGWQGALIATLMNAIA
LIASQTWHDHPVDLLLSLLAQSLTGLLLGAGIQRLRELNHSLQTELARNRRLAERLLETE
ESVRQEVARELHDDIGQTITAIRTQAGIVQRLAAENAGVKQGGAHIEQLSLGVYDSVRRL
LGRLRPRQLDDLTLEQAVRSLMREMELESRGIVSHLDWRINESLLSEGQRVTLFRVCQEG
LNNIVKHASASAVTLQGWQQDERLMLVIEDDGCGLPPGSGQLGFGLAGMRERVKALGGTL
TISCTHGTRVSVSLPLRSQHV