Protein Info for MMP_RS08810 in Methanococcus maripaludis S2

Annotation: DNA polymerase sliding clamp

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 TIGR00590: proliferating cell nuclear antigen (pcna)" amino acids 9 to 249 (241 residues), 144.3 bits, see alignment E=2.4e-46 PF04139: Rad9" amino acids 11 to 209 (199 residues), 37 bits, see alignment E=5.3e-13 PF00705: PCNA_N" amino acids 11 to 110 (100 residues), 70 bits, see alignment E=3.2e-23 PF02747: PCNA_C" amino acids 122 to 246 (125 residues), 54.5 bits, see alignment E=2.8e-18

Best Hits

Swiss-Prot: 100% identical to PCNA_METMP: DNA polymerase sliding clamp (pcn) from Methanococcus maripaludis (strain S2 / LL)

KEGG orthology group: K04802, proliferating cell nuclear antigen (inferred from 100% identity to mmp:MMP1711)

Predicted SEED Role

"DNA polymerase sliding clamp protein PCNA" in subsystem DNA replication, archaeal

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (archaea)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See Q6LWJ8 at UniProt or InterPro

Protein Sequence (250 amino acids)

>MMP_RS08810 DNA polymerase sliding clamp (Methanococcus maripaludis S2)
MFRATCNTRDFKKVINATSNLVDEICFEVDENGIKASAMDPSHVALVSMEMPKDVFEEYE
GDIQDIGIDLEALKKIIARGRGDEKLILDLDVEKNKLNITFKSNVTRKFSIALYDVSSSN
LKVPDIEYPNSVSIKAGAFVEALKDAELVNDHITLKIDENKFVIYSKGDLNQSETVFDNS
IDDDDNALADFNMGEASRSTFNLAYLKDLTKSTAAEDLLKIYLGSDMPVKIEYEVSGSKL
VFLLAPRIES