Protein Info for MMP_RS08780 in Methanococcus maripaludis S2

Annotation: 2-amino-5-formylamino-6-ribosylaminopyrimidin-4(3H)-one 5'-monophosphate deformylase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 221 transmembrane" amino acids 46 to 63 (18 residues), see Phobius details PF02633: Creatininase" amino acids 18 to 199 (182 residues), 51 bits, see alignment E=6.8e-18

Best Hits

Swiss-Prot: 100% identical to ARFB_METMP: 2-amino-5-formylamino-6-ribosylaminopyrimidin-4(3H)-one 5'-monophosphate deformylase (arfB) from Methanococcus maripaludis (strain S2 / LL)

KEGG orthology group: K14653, 2-amino-5-formylamino-6-ribosylaminopyrimidin-4(3H)-one 5'-monophosphate deformylase [EC: 3.5.1.102] (inferred from 100% identity to mmp:MMP1705)

Predicted SEED Role

"FO biosynthesis ArfB" in subsystem Riboflavin, FMN and FAD metabolism

MetaCyc Pathways

Isozymes

No predicted isozymes

Use Curated BLAST to search for 3.5.1.102

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (archaea)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See Q6LWK4 at UniProt or InterPro

Protein Sequence (221 amino acids)

>MMP_RS08780 2-amino-5-formylamino-6-ribosylaminopyrimidin-4(3H)-one 5'-monophosphate deformylase (Methanococcus maripaludis S2)
MIDLRYSSGNIFSESVHEIGIIALGSFLENHGSALPIDTDAKIASYIALNVSIITGAKFL
GIVLPSTEYSYVKHGIHDSIEDVINYIKYLVENGRKIGIKKFLIINCHGGNTIIEDELLK
LNSKDCFITMNSVCLTHASTEEVSLGYAVGILSEDKMKDHDPKVYGEIGMVGLTEAREKN
EAIDLEAKSVEENGVFLDKVNGKSLLNDLINNYVEIVKNMI