Protein Info for MMP_RS08485 in Methanococcus maripaludis S2

Annotation: tungstate ABC transporter substrate-binding protein WtpA

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 332 TIGR03730: tungstate ABC transporter binding protein WtpA" amino acids 25 to 297 (273 residues), 429 bits, see alignment E=3.3e-133 PF13531: SBP_bac_11" amino acids 26 to 298 (273 residues), 79.3 bits, see alignment E=3.8e-26 PF01547: SBP_bac_1" amino acids 41 to 299 (259 residues), 36.7 bits, see alignment E=5.1e-13

Best Hits

Swiss-Prot: 100% identical to Y1652_METMP: Uncharacterized solute-binding protein MMP1652 (MMP1652) from Methanococcus maripaludis (strain S2 / LL)

KEGG orthology group: K02061, putative sulfate transport system substrate-binding protein (inferred from 100% identity to mmp:MMP1652)

Predicted SEED Role

"Tungstate ABC transporter, periplasmic substrate-binding protein WtpA"

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (archaea)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See P61618 at UniProt or InterPro

Protein Sequence (332 amino acids)

>MMP_RS08485 tungstate ABC transporter substrate-binding protein WtpA (Methanococcus maripaludis S2)
MILAFSGCVDQSASDSTSEDATPKVLKIFHAGSLAVPFGEYETLYENEYTNVDVQRESAG
SVACVRKITELNKTAEILASADYTLIPSMMMPDYADWYVMVAKNEIVIAYTENSQYYDEI
TSDNWYEIFQRDGVKYGFSSPNDDPCGYRSQMVVQLAEEAYGDSTIYDNLMLGNTNFEVN
ENADGTYCIVSPESIDVNEAKVFMRSKEVDLLGPLETGAYDYLFIYKSVANQHGLSYIEL
PEDINLGDYQNADEYAKASIFLTGQNKTIVAKPIVYGMTVPSNAEDYEEGVNFVKTVLEH
PEVFENAGQPVISPAIAVGDVPEEISDLVVMG