Protein Info for MMP_RS08375 in Methanococcus maripaludis S2

Annotation: ATP-binding cassette domain-containing protein

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 549 PF00005: ABC_tran" amino acids 18 to 171 (154 residues), 75.2 bits, see alignment E=2.4e-24 amino acids 275 to 474 (200 residues), 101.1 bits, see alignment E=2.4e-32

Best Hits

Swiss-Prot: 66% identical to Y1662_METJA: Uncharacterized ABC transporter ATP-binding protein MJ1662 (MJ1662) from Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440)

KEGG orthology group: K00400, methyl coenzyme M reductase system, component A2 (inferred from 100% identity to mmp:MMP1630)

Predicted SEED Role

"Methyl coenzyme M reductase system component A2 homolog"

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (archaea)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See Q6LWS6 at UniProt or InterPro

Protein Sequence (549 amino acids)

>MMP_RS08375 ATP-binding cassette domain-containing protein (Methanococcus maripaludis S2)
MAVTVENLTKRYGEKVALDNVSFDVKKGDILGIIGKSGAGKTTLIKILRGVESFDEGKIE
VCGKTENLREITAIHLQRNFALWAEPAIYNIIRKLYAVRTDSDEGLPLEEEMEEYRKDAT
EILKLVGLEHKKDAYSNILSGGEKQRLILGRQLAKIYAKNGDGVLLLDEPATMACPASKQ
ILLDVLKNINEKLGVTIIVTSHLPEIHKYLCKSCILIENGKIIMKDTPEKVVDEFLKDMV
EAYDRLSKPTDKTVVEVEDASKRYYVVNGGETLNLKDISFKVKEKEILSILGPSGTGKSV
ILRLLAGLEAPDKGVVKLEGIDLKDFGWNRMNLRRKIGIMHQEFSLAHYLTVNELLKYRL
GVKSIETVESAKLKAAELGISPKMVDGLYQLLDLPETEMRNKLDKIGISEMVVRKLFPAK
PVEYDANELLEALDLNKETLNKKPTELSGGEKVRVAMALQLALEPDILLLDEPFGDLDPL
TLREVSNYLKKINDTVGTTIILISHHVELIKEISDRAILIDEGKLLMNGNPEEICEKFIE
RSNSKFMNQ