Protein Info for MMP_RS08140 in Methanococcus maripaludis S2

Annotation: adenosylmethionine decarboxylase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• TIGR03330: S-adenosylmethionine decarboxylase proenzyme
  • amino acids 3 to 113 (111 residues), 154.5 bits, E=6.1e-50
• PF02675: AdoMet_dc
  • amino acids 7 to 113 (107 residues), 139.6 bits, E=2.3e-45

Best Hits

Swiss-Prot: 99% identical to SPEH_METMP: S-adenosylmethionine decarboxylase proenzyme (speH) from Methanococcus maripaludis (strain S2 / LL)

KEGG orthology group: K01611, S-adenosylmethionine decarboxylase [EC: 4.1.1.50] (inferred from 99% identity to mmp:MMP1583)

Predicted SEED Role

"S-adenosylmethionine decarboxylase proenzyme (EC 4.1.1.50), prokaryotic class 1B" in subsystem Polyamine Metabolism (EC 4.1.1.50)

MetaCyc Pathways

• superpathway of arginine and polyamine biosynthesis (13/17 steps found)
• spermidine biosynthesis I (2/2 steps found)
• spermine biosynthesis (1/2 steps found)
• spermidine biosynthesis III (2/4 steps found)
• aminopropylcadaverine biosynthesis (1/3 steps found)
• superpathway of polyamine biosynthesis I (4/8 steps found)
• superpathway of polyamine biosynthesis II (3/8 steps found)
• L-methionine salvage cycle III (5/11 steps found)
• L-methionine salvage cycle I (bacteria and plants) (4/12 steps found)

KEGG Metabolic Maps

• Arginine and proline metabolism
• Methionine metabolism
• Urea cycle and metabolism of amino groups

Isozymes

No predicted isozymes

Use Curated BLAST to search for 4.1.1.50

Sequence Analysis Tools

See Q6LWX1 at UniProt or InterPro

Protein Sequence (122 amino acids)

>MMP_RS08140 adenosylmethionine decarboxylase (Methanococcus maripaludis S2)
LKQLGKHIILELWGCESQALDDQPGIEKMLVNAVKACGATLICVKTHKFSPQGVTGVAVL
SESHISIHTWPELGYAAMDVFTCGEHVKPEDTIPEIEKFLKPEKTEVMDIKRGIIDDGEV
KE