Protein Info for MMP_RS07980 in Methanococcus maripaludis S2
Annotation: UbiX family flavin prenyltransferase
These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.
Protein Families and Features
Best Hits
Swiss-Prot: 71% identical to UBIX_METJA: Flavin prenyltransferase UbiX (ubiX) from Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440)
KEGG orthology group: K03186, 3-octaprenyl-4-hydroxybenzoate carboxy-lyase UbiX [EC: 4.1.1.-] (inferred from 100% identity to mmp:MMP1552)MetaCyc: 46% identical to gallate decarboxylase B subunit (Lactiplantibacillus plantarum WCFS1)
Protocatechuate decarboxylase. [EC: 4.1.1.63]; Gallate decarboxylase. [EC: 4.1.1.63, 4.1.1.59]
Predicted SEED Role
"UbiX family decarboxylase associated with menaquinone via futalosine"
MetaCyc Pathways
- gallate degradation III (anaerobic) (1/11 steps found)
KEGG Metabolic Maps
- 1,1,1-Trichloro-2,2-bis(4-chlorophenyl)ethane (DDT) degradation
- 1- and 2-Methylnaphthalene degradation
- 3-Chloroacrylic acid degradation
- Ascorbate and aldarate metabolism
- Benzoate degradation via CoA ligation
- Benzoate degradation via hydroxylation
- Biphenyl degradation
- Fluorene degradation
- Phenylalanine metabolism
- Phenylpropanoid biosynthesis
- Purine metabolism
- Pyruvate metabolism
- Tryptophan metabolism
- Tyrosine metabolism
- Ubiquinone and menaquinone biosynthesis
Isozymes
Compare fitness of predicted isozymes for: 4.1.1.-
Use Curated BLAST to search for 4.1.1.- or 4.1.1.59 or 4.1.1.63
Sequence Analysis Tools
PaperBLAST (search for papers about homologs of this protein)
Search CDD (the Conserved Domains Database, which includes COG and superfam)
Compare to protein structures
Predict protein localization: PSORTb (archaea)
Predict transmembrane helices and signal peptides: Phobius
Check the current SEED with FIGfam search
Find homologs in fast.genomics or the ENIGMA genome browser
See Q6LX02 at UniProt or InterPro
Protein Sequence (185 amino acids)
>MMP_RS07980 UbiX family flavin prenyltransferase (Methanococcus maripaludis S2) MDEIIVCITGASGVIYSKRLLEVLKEENIKTSLIISNSAKKIIKHELKMEIDEFKKLADN YYENDNFFSPVASGSHKFKAAVVIPCSMKSLSSIATGYSDNLIGRVCDIALKERRDLIIV PREMPFSTIHLENMTKLSHLGVSIIPPAPGFYNDPKTIDDLVNFVVGRILDNLKIENKIF KRWGE