Protein Info for MMP_RS07855 in Methanococcus maripaludis S2

Annotation: class I SAM-dependent methyltransferase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 236 PF01209: Ubie_methyltran" amino acids 2 to 145 (144 residues), 23.3 bits, see alignment E=1.2e-08 PF13489: Methyltransf_23" amino acids 49 to 163 (115 residues), 37.8 bits, see alignment E=5.1e-13 PF13847: Methyltransf_31" amino acids 53 to 147 (95 residues), 32.5 bits, see alignment E=1.9e-11 PF13649: Methyltransf_25" amino acids 58 to 140 (83 residues), 41.8 bits, see alignment E=4.5e-14 PF08241: Methyltransf_11" amino acids 59 to 144 (86 residues), 60.3 bits, see alignment E=7.2e-20

Best Hits

KEGG orthology group: None (inferred from 100% identity to mmp:MMP1529)

Predicted SEED Role

"Methyltransferase type 11"

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (archaea)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See Q6LX24 at UniProt or InterPro

Protein Sequence (236 amino acids)

>MMP_RS07855 class I SAM-dependent methyltransferase (Methanococcus maripaludis S2)
MNKLKSDEVKAFYENWDVSKYPDYLKLLMEFEENLIFKIILEDDFFKSLSKSHKNTKILD
CGCGFGSFYNLTKDFDTLYLDFSLNLLKKFKIEKNKICANIENLPFKNGIFDLILCINVL
EHVDFEKAVFEVKRVLKTNGRAYFIVVNADSIINDEIFVDWKIPHNLISKSDFKSIETDD
FKIEYIISFYFLHPFFKLFPKLILKRIIDLFFKNDEKISKVLKFKGQFLICKMVKK