Protein Info for MMP_RS07460 in Methanococcus maripaludis S2

Annotation: DUF2109 domain-containing protein

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 25 50 75 88 transmembrane" amino acids 6 to 23 (18 residues), see Phobius details amino acids 30 to 48 (19 residues), see Phobius details amino acids 54 to 76 (23 residues), see Phobius details PF09882: DUF2109" amino acids 5 to 80 (76 residues), 111.9 bits, see alignment E=5.9e-37

Best Hits

Swiss-Prot: 52% identical to Y52A_METJA: Uncharacterized protein MJ0526.1 (MJ0526.1) from Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440)

KEGG orthology group: K14094, energy-converting hydrogenase A subunit C (inferred from 100% identity to mmp:MMP1450)

Predicted SEED Role

"Energy conserving hydrogenase Eha transmembrane protein C"

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (archaea)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See Q6LXA2 at UniProt or InterPro

Protein Sequence (88 amino acids)

>MMP_RS07460 DUF2109 domain-containing protein (Methanococcus maripaludis S2)
MESLVTVTIGLIGIISVIKVFLTKSRALKLPIICCINFCIAALIALYIKSPMGAVAAVVY
FALSTVSSNAIAHTLGEIDKMDEFEKKR