Protein Info for MMP_RS07130 in Methanococcus maripaludis S2

Annotation: coenzyme F420 hydrogenase subunit gamma

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 228 signal peptide" amino acids 1 to 21 (21 residues), see Phobius details TIGR03294: coenzyme F420 hydrogenase, subunit gamma" amino acids 2 to 228 (227 residues), 361.4 bits, see alignment E=1.1e-112 PF01058: Oxidored_q6" amino acids 12 to 139 (128 residues), 106.6 bits, see alignment E=3.1e-34 PF13237: Fer4_10" amino acids 170 to 216 (47 residues), 32.1 bits, see alignment 3.5e-11 PF00037: Fer4" amino acids 170 to 191 (22 residues), 32.2 bits, see alignment (E = 2.7e-11) PF12838: Fer4_7" amino acids 176 to 216 (41 residues), 28.6 bits, see alignment 6.5e-10 PF13187: Fer4_9" amino acids 176 to 217 (42 residues), 29.2 bits, see alignment 3.1e-10

Best Hits

Swiss-Prot: 79% identical to FRHG_METJA: Coenzyme F420 hydrogenase subunit gamma (frhG) from Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440)

KEGG orthology group: K00443, coenzyme F420 hydrogenase gamma subunit [EC: 1.12.98.1] (inferred from 100% identity to mmp:MMP1384)

MetaCyc: 51% identical to factor F420-reducing hydrogenase gamma subunit (Methanosarcina barkeri)
Coenzyme F420 hydrogenase. [EC: 1.12.98.1]

Predicted SEED Role

"Coenzyme F420 hydrogenase gamma subunit (FruG) (EC 1.12.98.1)" in subsystem Coenzyme F420 hydrogenase (EC 1.12.98.1)

MetaCyc Pathways

KEGG Metabolic Maps

Isozymes

Compare fitness of predicted isozymes for: 1.12.98.1

Use Curated BLAST to search for 1.12.98.1

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (archaea)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See Q6LXG7 at UniProt or InterPro

Protein Sequence (228 amino acids)

>MMP_RS07130 coenzyme F420 hydrogenase subunit gamma (Methanococcus maripaludis S2)
MVKVAHVQLSSCCGCLVSLADTYEQLLDVLGAIDLVYSQTLADVREIPDDVDIVLLEGSV
CLSDHHAMEVALESRKKGKILVALGACAASGNITRFSKGNQPSKPVHDSFAPLTEVVKCD
LAIPGCPPSPESIVAVVLAALNGDMEYLEPYAELAKYGSEACGCDLIVKVINKSLCMGCG
SCAAACPTRAVSMDAGRPLVDKEICIKCGACSVQCPRIRFPELIEKIE