Protein Info for MMP_RS07045 in Methanococcus maripaludis S2

Annotation: NusA-like transcription termination signal-binding factor

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 173 TIGR01952: NusA family KH domain protein, archaeal" amino acids 1 to 140 (140 residues), 188.4 bits, see alignment E=3.9e-60 PF07650: KH_2" amino acids 12 to 81 (70 residues), 35.7 bits, see alignment E=9.5e-13 PF13184: KH_5" amino acids 31 to 90 (60 residues), 60.1 bits, see alignment E=2.7e-20

Best Hits

Swiss-Prot: 90% identical to NUSA_METVS: Probable transcription termination protein NusA (nusA) from Methanococcus vannielii (strain ATCC 35089 / DSM 1224 / JCM 13029 / OCM 148 / SB)

KEGG orthology group: K02600, N utilization substance protein A (inferred from 100% identity to mmp:MMP1366)

Predicted SEED Role

"NusA protein homolog, archaeal"

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (archaea)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See Q6LXI5 at UniProt or InterPro

Protein Sequence (173 amino acids)

>MMP_RS07045 NusA-like transcription termination signal-binding factor (Methanococcus maripaludis S2)
MRIKLNTEDIMRISLFEKMTGADVIDSTSDDEKIVFVVKEGDIGAAIGKGGENVRNATEK
FGKKIDLIEYSEDVKQFIKNIFAPIEVEDVWTKKFGDDLVVYIRVHPRFRRAIIGDKGKN
IDRAVDIAGRLAGVKNIKVVAGLRKDNDKKPKQEEVPEKAAESSKNVEAEENQ