Protein Info for MMP_RS06930 in Methanococcus maripaludis S2

Annotation: MBL fold metallo-hydrolase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 266 PF13483: Lactamase_B_3" amino acids 23 to 187 (165 residues), 27.9 bits, see alignment E=3.2e-10 PF12706: Lactamase_B_2" amino acids 34 to 217 (184 residues), 68.3 bits, see alignment E=1.1e-22 PF00753: Lactamase_B" amino acids 37 to 75 (39 residues), 23.6 bits, see alignment 6.7e-09

Best Hits

Swiss-Prot: 55% identical to Y1374_METJA: Uncharacterized protein MJ1374 (MJ1374) from Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440)

KEGG orthology group: None (inferred from 100% identity to mmp:MMP1343)

Predicted SEED Role

"Uncharacterized protein MJ1374"

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (archaea)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See Q6LXK7 at UniProt or InterPro

Protein Sequence (266 amino acids)

>MMP_RS06930 MBL fold metallo-hydrolase (Methanococcus maripaludis S2)
LLEIVFLGGGGGRWESITQVKGTGGFRIHSEDMNMHVDPGTGALVRMNQLEINPWKTDAI
ITTHCHPDHYTDAECLVEAMTKGMTKKQGILIGNNSVLNGNSKFEKGISTYHQSRVGERH
ILSPDDELNVKKWKLTATKTKHNDPETIGFKVETDDGVIGYTSDSEYIDSLIEDFDSVDF
LIANVIRVKGQKVPGHMCSNDIIEIVNSMNKTPKMLTMYHMGMKMTDPDSEARYISKNID
IPVIPAKIGLKITMENKNCKFDYIKY