Protein Info for MMP_RS06770 in Methanococcus maripaludis S2

Annotation: DHH family phosphoesterase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 600 650 700 761 PF00575: S1" amino acids 132 to 197 (66 residues), 31.7 bits, see alignment E=2.5e-11 PF01368: DHH" amino acids 366 to 488 (123 residues), 33.6 bits, see alignment E=6.5e-12

Best Hits

Swiss-Prot: 66% identical to Y1198_METJA: Uncharacterized protein MJ1198 (MJ1198) from Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440)

KEGG orthology group: K07463, archaea-specific RecJ-like exonuclease (inferred from 100% identity to mmp:MMP1314)

Predicted SEED Role

"Uncharacterized protein MJ1198"

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (archaea)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See Q6LXN5 at UniProt or InterPro

Protein Sequence (761 amino acids)

>MMP_RS06770 DHH family phosphoesterase (Methanococcus maripaludis S2)
MIENCKICGGTGKKVVKYAECPECEGTGYLEEFETKSHFKNASKNSKYDFDDEEIPCPTC
NGSGKIPEYEDCDYCNGTGKVVKCDSCGCEIGKYPEDKDLKICENCKQKEDVKNDNKKVV
YVLDNMFTMNDLEEGKFYKGKINRTEKYGVFVQLNEKTRGLLRFREVVGKRPSDFKIGDE
IIVQVSELKLEKRELDLRYVPIAGYRLEKLEKEHELIDIKEIFDTGLMNMKDKVIRVQGE
VLQAAQTPGPTVFTITDGSEVAWVAAFESAGVRTHPDVVMGSIIDVVGSVSVRDGKLQIE
RMKLVKLEGDEEQKVKDKIDVELDKKAEPESDIEFLVESDILEKLRPKMADVAKRIRRAV
LDGRPVIIRHHADTDGYCGGIALEKAIVPILEKFSMDSGAQWHYFRRSPSKAPFYELEDV
TKDLLFSIEDYLRFGQKMPLIVLVDNGSTDEDIPAVSQVKAYDIEVVVVDHHFPGEVIDG
KVEIDEFVEAHVNPYLVGGDSNLTAGALATEVARMINSEVTDLVEHLPGIAVVGDHAKGD
AVEAYIKIALERLTKCSAEFGSGKIYSREDVEKIGQCMDFEAFYLKFMNGMGIVEDIYGM
NKKDFARHEKLIKILYERAMAMVDRQMKAVRPAIKTKTMPNGIIYNTLDVEKYAHKFTFP
APGKTCGFAHDSIVEQHEPGTPVITLSYGPDFAVVRATDAVSEKFNFNLNHIVTQFIDEI
PEASLDGGGHECAGSLKFVEGLREKVINRFSEVVLEMKEKN