Protein Info for MMP_RS06605 in Methanococcus maripaludis S2

Annotation: DUF5814 domain-containing protein

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 600 650 700 750 811 PF00270: DEAD" amino acids 207 to 372 (166 residues), 95.8 bits, see alignment E=5.1e-31 PF04851: ResIII" amino acids 218 to 367 (150 residues), 43.8 bits, see alignment E=5.3e-15 PF00271: Helicase_C" amino acids 423 to 524 (102 residues), 61.4 bits, see alignment E=1.9e-20 PF19131: DUF5814" amino acids 667 to 805 (139 residues), 103.3 bits, see alignment E=1.9e-33

Best Hits

KEGG orthology group: K03725, archaea-specific helicase [EC: 3.6.1.-] (inferred from 100% identity to mmp:MMP1284)

Predicted SEED Role

"Archaea-specific Superfamily II helicase MJ1401"

KEGG Metabolic Maps

Isozymes

Compare fitness of predicted isozymes for: 3.6.1.-

Use Curated BLAST to search for 3.6.1.-

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (archaea)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See Q6LXR5 at UniProt or InterPro

Protein Sequence (811 amino acids)

>MMP_RS06605 DUF5814 domain-containing protein (Methanococcus maripaludis S2)
MIIVRKLKKKKEEIQFIDLTDEKTYYGIIRPANNRITLYKCREEKAGNVNPIQPSKLINF
VRSNKVLLSGDEESLKLEEFLKQNNIKHGYIDLCPFCIIKGKFSEITDKYKIYNSEICLE
CAIDEVKHEININEEFIEKLLRRFKDANKVIELFKSKNPLKNPELTKYDVLTGNVDDNIK
NYGINELDIPDFLKEIIKNRGIDELLPVQTLSVKAGLLKNDNLLITSATSSGKTLIGELA
GIKNISEKKGKFLFLVPLVALANQKYVEFKDRYEKEGYSVSLRVGTGRLSENKGGGINSS
LDSDIIIGTYEGIDYLIRSGKLKDVGTVVIDEVHSMNMDERGARLDGLIGRLRYLFTCQM
IYLSATVGNPEELASKLGSKLVLYNGRPVPLERHLIFTKNDYGKLNLVNDIVKQEFSSKS
KYGFRGQSLIFTFSRKRAEYISNYLNTKGIKSDYYHGGMEYSKRRTVEDNFLKQKTMCVV
TTAALAAGVDFAASTVVLESLAMGGDWLNPSEFQQMCGRAGRKGMHDKGKVYSLVEIGKK
YHAKMENSEDEVSFKLLNSEPEEVSLEYSEDEEFEQVLANVCSIKNYKNKVTIPDVSKVP
VLGKNLGLNYVLESLSGYQMLDLQNKNINTTRYGYATSISFLYPKDAEKIRKNLHKNPLD
IVVSISPFENAYIPANLKNKISKTTNVNIPTRFTDAFEVIKENFEKIKDKTLRDEILPWL
IEFDGLIEEDIINYNSKKVLNLRINKKTPLQISKIIHDTLKLQTYSGDIYSYLETSINTL
DAVERIGNIYNKKIAKESAKLKKKMENPYKN