Protein Info for MMP_RS06405 in Methanococcus maripaludis S2

Annotation: 4Fe-4S binding protein

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 352 PF12838: Fer4_7" amino acids 31 to 85 (55 residues), 35.3 bits, see alignment 7.7e-12 amino acids 114 to 168 (55 residues), 33.9 bits, see alignment 2.1e-11 amino acids 154 to 208 (55 residues), 33.2 bits, see alignment 3.7e-11 amino acids 274 to 325 (52 residues), 36.6 bits, see alignment 3.1e-12 PF12798: Fer4_3" amino acids 32 to 46 (15 residues), 13.8 bits, see alignment (E = 5.6e-05) amino acids 311 to 325 (15 residues), 17.4 bits, see alignment (E = 3.7e-06) PF00037: Fer4" amino acids 32 to 48 (17 residues), 22.3 bits, see alignment (E = 5.5e-08) amino acids 68 to 86 (19 residues), 22.2 bits, see alignment (E = 5.9e-08) amino acids 148 to 170 (23 residues), 27.7 bits, see alignment (E = 1.1e-09) amino acids 187 to 210 (24 residues), 30.8 bits, see alignment (E = 1.1e-10) amino acids 237 to 258 (22 residues), 31.1 bits, see alignment (E = 9.1e-11) amino acids 304 to 327 (24 residues), 29.4 bits, see alignment (E = 3e-10) PF13187: Fer4_9" amino acids 32 to 84 (53 residues), 32.3 bits, see alignment 5.1e-11 PF12800: Fer4_4" amino acids 152 to 166 (15 residues), 10 bits, see alignment (E = 0.00065) amino acids 240 to 254 (15 residues), 12.7 bits, see alignment (E = 9.1e-05) amino acids 273 to 285 (13 residues), 11.3 bits, see alignment (E = 0.00025) amino acids 309 to 323 (15 residues), 17.7 bits, see alignment (E = 2.1e-06) PF13237: Fer4_10" amino acids 236 to 285 (50 residues), 31.7 bits, see alignment 7e-11

Best Hits

Swiss-Prot: 64% identical to FWDF_METJA: Polyferredoxin protein FwdF (fwdF) from Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440)

KEGG orthology group: K00205, formylmethanofuran dehydrogenase subunit F [EC: 1.2.99.5] (inferred from 100% identity to mmp:MMP1245)

Predicted SEED Role

"Formylmethanofuran dehydrogenase (tungsten) operon gene F (polyferredoxin)" in subsystem Methanogenesis

KEGG Metabolic Maps

Isozymes

Compare fitness of predicted isozymes for: 1.2.99.5

Use Curated BLAST to search for 1.2.99.5

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (archaea)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See Q6LXV1 at UniProt or InterPro

Protein Sequence (352 amino acids)

>MMP_RS06405 4Fe-4S binding protein (Methanococcus maripaludis S2)
MKNFKKDENDGVIEISRSGVEKRVLKWDDCTCVGCGICSEICPTSAIEMGPLGAIFKGDI
DAPKLDISEKCVLCGMCACACPFDAVKLSINDKPITEMPQYPKIKRGIELNQSKCVLCEQ
CELVCPQCAIDVEREVPERKSLVLGEITIKKDDCVLCGICAEYCPADAIELIPNDMNALS
LNPIADIKIDLDACVYCKVCEKACPHNAIEAICYKCPLASKIKKPELYGEIKGQTNIDKE
LCVSCGWCANICPADAIEVEKPFEGELIIDEPACNACGACISVCPCNALVFPQPEKQGDK
VPNVVVNQDVCILCGACTHSCPVDALTVKRTKINMTEANAPAWKKAFSKLMK