Protein Info for MMP_RS06390 in Methanococcus maripaludis S2

Annotation: quinolinate synthase NadA

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• TIGR00550: quinolinate synthetase complex, A subunit
  • amino acids 3 to 305 (303 residues), 383.6 bits, E=3.3e-119
• PF02445: NadA
  • amino acids 5 to 303 (299 residues), 360.9 bits, E=2.3e-112

Best Hits

Swiss-Prot: 70% identical to NADA_METJA: Quinolinate synthase A (nadA) from Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440)

KEGG orthology group: K03517, quinolinate synthase [EC: 2.5.1.72] (inferred from 100% identity to mmp:MMP1242)

Predicted SEED Role

"Quinolinate synthetase (EC 2.5.1.72)" in subsystem NAD and NADP cofactor biosynthesis global or NAD regulation (EC 2.5.1.72)

MetaCyc Pathways

• aspartate superpathway (18/25 steps found)
• NAD de novo biosynthesis III (4/6 steps found)
• NAD de novo biosynthesis I (3/6 steps found)
• NAD de novo biosynthesis IV (anaerobic) (3/6 steps found)
• nicotine biosynthesis (2/9 steps found)
• superpathway of nicotine biosynthesis (3/12 steps found)

Isozymes

No predicted isozymes

Use Curated BLAST to search for 2.5.1.72

Sequence Analysis Tools

See Q6LXV4 at UniProt or InterPro

Protein Sequence (305 amino acids)

>MMP_RS06390 quinolinate synthase NadA (Methanococcus maripaludis S2)
MDIIERITKLKNEKNAVILAHNYQPEEIQKIADIIGDSLELCIAARDTDADVIVFCGVDF
MAETAKVLNSGKKVLIPEIIETDCPMAHQLPPEIILEAKKKNPDAKVVIYVNTLASAKAL
ADATCTSANADKVVNSFEEDEILFGPDNNLGYFVSKRSNKKIIPMPEGGHCYVHKMFTLD
DAKAVKEKYPNAELLIHPESDPKLQETADYVMSTGGMVKHVLNSECSEFIIGTECDMISR
LKIELEKAGKSKKLIPLRTDAICKSMKNITLEKIEKCLLEEKHEIMLDEKIIENARKAIE
RMLSI