Protein Info for MMP_RS06300 in Methanococcus maripaludis S2

Annotation: ABC transporter substrate-binding protein

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 254 signal peptide" amino acids 1 to 25 (25 residues), see Phobius details PF00497: SBP_bac_3" amino acids 38 to 253 (216 residues), 110.8 bits, see alignment E=4.2e-36 PF12974: Phosphonate-bd" amino acids 64 to 243 (180 residues), 29.4 bits, see alignment E=5.2e-11

Best Hits

KEGG orthology group: K02030, polar amino acid transport system substrate-binding protein (inferred from 100% identity to mmp:MMP1224)

Predicted SEED Role

"Glutamine ABC transporter, periplasmic glutamine-binding protein (TC 3.A.1.3.2)" (TC 3.A.1.3.2)

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (archaea)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See Q6LXX2 at UniProt or InterPro

Protein Sequence (254 amino acids)

>MMP_RS06300 ABC transporter substrate-binding protein (Methanococcus maripaludis S2)
VKIPTILVIISSILILTSFSGCTSSYGKEYNTVNPGVLTVGITPEMPPQQYYEDGELKGF
DIDLMKEIANNMGLKPEFKIYEYGGAHEALLNGEIDCLPSMTISPERKEDMDFSRAYIQT
YVVVAVFENSPYRELKDLNGKNIAVVTNTYTEDWAKEYLGSLNANIKSYDSVEGLVSDVY
SGNIDAVVTDQIQLDYYSKQNNFESRLIFEKMTIEYWAIAVKKDNHNLQNEINDVLFELD
ENKALYELKNKWYD