Protein Info for MMP_RS06195 in Methanococcus maripaludis S2

Annotation: cobalt-precorrin-5B (C(1))-methyltransferase CbiD

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• PF01888: CbiD
  • amino acids 12 to 273 (262 residues), 302.9 bits, E=8.4e-95
• TIGR00312: cobalamin biosynthesis protein CbiD
  • amino acids 17 to 362 (346 residues), 434.1 bits, E=1.6e-134

Best Hits

Swiss-Prot: 100% identical to CBID_METMP: Cobalt-precorrin-5B C(1)-methyltransferase (cbiD) from Methanococcus maripaludis (strain S2 / LL)

KEGG orthology group: K02188, cobalamin biosynthesis protein CbiD (inferred from 100% identity to mmp:MMP1203)

Predicted SEED Role

"Cobalt-precorrin-6 synthase, anaerobic" in subsystem Cobalamin synthesis or Coenzyme B12 biosynthesis

MetaCyc Pathways

• cob(II)yrinate a,c-diamide biosynthesis I (early cobalt insertion) (14/15 steps found)
• adenosylcobalamin biosynthesis I (anaerobic) (29/36 steps found)

Sequence Analysis Tools

See P61988 at UniProt or InterPro

Protein Sequence (365 amino acids)

>MMP_RS06195 cobalt-precorrin-5B (C(1))-methyltransferase CbiD (Methanococcus maripaludis S2)
MGKIDFRLEKTFGYTTGACAAAGAFSALYFLKNNEKLRFVEILNLKGDSLIIPIKNIEKQ
KNTAISTVEKFSGEDIDITNGMDIKIEVTLEKLDNNSSKSSSVKIIGGDGVGIVTKSGLQ
VNPGEYAINPKPREMIENNLKSLLENDECVTAKISVPNGDEIAKKTLNPKLGIIGGISIL
GTTGIVRPMSNDAYKESLAPQIDVALAYNFENLIFVPGNIGTKHAKILLNAKEDQIIEVS
NFWDYMLDKAKEKGVKDITVFGHAGKIVKLAGGIFDTHSRVADARNEILCAYTSLITQDV
EMLQKILQSNTTEDIVEILTEKGILTEVFEKVSKRVVERLSLRWEKINFSCIIIDMKGNI
LGKSD