Protein Info for MMP_RS06040 in Methanococcus maripaludis S2

Annotation: CDP-diacylglycerol--serine O-phosphatidyltransferase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 204 transmembrane" amino acids 7 to 29 (23 residues), see Phobius details amino acids 78 to 101 (24 residues), see Phobius details amino acids 112 to 132 (21 residues), see Phobius details amino acids 138 to 156 (19 residues), see Phobius details amino acids 168 to 197 (30 residues), see Phobius details PF01066: CDP-OH_P_transf" amino acids 6 to 148 (143 residues), 54.2 bits, see alignment E=1.1e-18 TIGR00473: CDP-diacylglycerol-serine O-phosphatidyltransferase" amino acids 15 to 161 (147 residues), 140.5 bits, see alignment E=2.4e-45

Best Hits

Swiss-Prot: 58% identical to PSS_METJA: CDP-diacylglycerol--serine O-phosphatidyltransferase (pssA) from Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440)

KEGG orthology group: K00998, phosphatidylserine synthase [EC: 2.7.8.8] (inferred from 100% identity to mmp:MMP1171)

Predicted SEED Role

"CDP-diacylglycerol--serine O-phosphatidyltransferase (EC 2.7.8.8)" in subsystem Glycerolipid and Glycerophospholipid Metabolism in Bacteria (EC 2.7.8.8)

MetaCyc Pathways

KEGG Metabolic Maps

Isozymes

No predicted isozymes

Use Curated BLAST to search for 2.7.8.8

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (archaea)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See Q6LY22 at UniProt or InterPro

Protein Sequence (204 amino acids)

>MMP_RS06040 CDP-diacylglycerol--serine O-phosphatidyltransferase (Methanococcus maripaludis S2)
MFKIRNIITISDYVTVINIIFGMLAILLHDFRFVYISIVFDALDGVVARKTNTVSEFGAE
LDSICDVVSFGVAPAYLIYYYFDSTVSIIGSIIFLIGGALRLARFGILDVKHFIGLPIPA
AALFLCILTQMSLKYGFGSGYVVSIIAVISGILMISDINYPKYPKKPLLVVFGISIILSM
FGVIEPLAICAVLYVLYGIFKMKM