Protein Info for MMP_RS05940 in Methanococcus maripaludis S2

Annotation: corrinoid protein

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 215 PF02607: B12-binding_2" amino acids 7 to 80 (74 residues), 77.9 bits, see alignment E=5.4e-26 PF02310: B12-binding" amino acids 92 to 205 (114 residues), 95.9 bits, see alignment E=1.6e-31

Best Hits

Swiss-Prot: 50% identical to MTBC2_METMA: Dimethylamine corrinoid protein 2 (mtbC2) from Methanosarcina mazei (strain ATCC BAA-159 / DSM 3647 / Goe1 / Go1 / JCM 11833 / OCM 88)

KEGG orthology group: None (inferred from 100% identity to mmp:MMP1151)

MetaCyc: 43% identical to glycine betaine-specific corrinoid protein (Desulfitobacterium hafniense Y51)

Predicted SEED Role

"Dimethylamine corrinoid protein 2"

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (archaea)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See Q6LY42 at UniProt or InterPro

Protein Sequence (215 amino acids)

>MMP_RS05940 corrinoid protein (Methanococcus maripaludis S2)
VTKEQILKDIAENLVEMEPERVVELCNEALNLGILPEEIIDNGLIAGMDEVGNLYEEEEY
FVPEVLICADALYAGLDVVKPHITTEDATKPIKVVIGVVQGDTHDIGKNLVKIMMGASGI
DVHDLGRDVPLEQFIEKAEEIEADFIGMSTLMTTTMDGMEKVIKMLEEKGLRNKYKVFIG
GGPISQSFADKIGADIYTNTANEAVRRVKEVYGGL